Synthesis of 2,2,4-Trimethyl-2,3-dihydro-1H-1,5-benzodiazepine using Treated Natural Zeolite Catalyst
The cyclocondensation of 1,2-phenylenediamine and acetone in the presence of treated natural zeolite catalyst (TNZ) under solvent-free condition has been done. The research consisted of three steps. The first step was treatment of natural zeolite by mixing this material in hydrochloric acid solution...
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Department of Chemical Engineering - Diponegoro University,
2019-04-15.
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| LEADER | 02629 am a22003133u 4500 | ||
|---|---|---|---|
| 001 | BCREC_UNDIP_2222_2216 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Firdaus, Maulidan |e author |
| 100 | 1 | 0 | |e contributor |
| 700 | 1 | 0 | |a Prameswari, Meyta Dyah |e author |
| 245 | 0 | 0 | |a Synthesis of 2,2,4-Trimethyl-2,3-dihydro-1H-1,5-benzodiazepine using Treated Natural Zeolite Catalyst |
| 260 | |b Department of Chemical Engineering - Diponegoro University, |c 2019-04-15. | ||
| 500 | |a https://ejournal2.undip.ac.id/index.php/bcrec/article/view/2222 | ||
| 520 | |a The cyclocondensation of 1,2-phenylenediamine and acetone in the presence of treated natural zeolite catalyst (TNZ) under solvent-free condition has been done. The research consisted of three steps. The first step was treatment of natural zeolite by mixing this material in hydrochloric acid solution at 50 °C for 1 hour to be followed by soaking the zeolite in ammonium chloride solution for 5 days. The second step was solvent-free condensation of 1,2-phenylenediamine and acetone using TNZ at 50 °C for 2 hours with weight ratio variation of catalyst, i.e. 15, 30, 45, and 60% (wt/wt). The third step was to study catalyst reusability for the condensation reaction. Based on TLC, FTIR, and 1H NMR analyses, the condensation afforded 2,2,4-trimethyl-2,3-dihydro-1H-1,5-benzodiazepine as the product in 73% yield with the optimum of catalyst loading at 30% (wt/wt). The reusability test showed that the catalyst can be reused for the cyclocondensation for four times. | ||
| 540 | |a Copyright (c) 2019 by Authors, Published by BCREC Group | ||
| 540 | |a http://creativecommons.org/licenses/by-sa/4.0 | ||
| 546 | |a eng | ||
| 690 | |a 1,5-Benzodiazepine; Catalyst Reusability; Heterogenous Catalyst; Natural Zeolite; Solvent-Free | ||
| 655 | 7 | |a info:eu-repo/semantics/article |2 local | |
| 655 | 7 | |a info:eu-repo/semantics/publishedVersion |2 local | |
| 655 | 7 | |2 local | |
| 786 | 0 | |n Bulletin of Chemical Reaction Engineering & Catalysis; 2019: BCREC Volume 14 Issue 1 Year 2019 (April 2019); 9-16 | |
| 786 | 0 | |n 1978-2993 | |
| 787 | 0 | |n https://ejournal2.undip.ac.id/index.php/bcrec/article/view/2222/2216 | |
| 787 | 0 | |n https://ejournal2.undip.ac.id/index.php/bcrec/article/downloadSuppFile/2222/470 | |
| 787 | 0 | |n https://ejournal2.undip.ac.id/index.php/bcrec/article/downloadSuppFile/2222/471 | |
| 856 | 4 | 1 | |u https://ejournal2.undip.ac.id/index.php/bcrec/article/view/2222/2216 |z Get Fulltext |
| 856 | 4 | 1 | |u https://ejournal2.undip.ac.id/index.php/bcrec/article/downloadSuppFile/2222/470 |z Get Fulltext |
| 856 | 4 | 1 | |u https://ejournal2.undip.ac.id/index.php/bcrec/article/downloadSuppFile/2222/471 |z Get Fulltext |