Chapter 14 Coupled Enzyme Activity and Thermal Shift Screening of the Maybridge Rule of 3 Fragment Library Against Trypanosoma brucei Choline Kinase; A Genetically Validated Drug Target
In this study we interrogate 630 compounds of the Maybridge Rule of 3 Fragment Library for compounds that interact with, and inhibit TbCK. The Maybridge Rule of 3 Fragment Library is a small collection of quantifiable diverse, pharmacophoric rich, chemical entities that comply with the following cri...
Saved in:
Main Author: | Denton, Helen (auth) |
---|---|
Other Authors: | Major, Louise L. (auth), Smith, Terry K. (auth) |
Format: | Book Chapter |
Published: |
InTechOpen
2013
|
Subjects: | |
Online Access: | Get Fullteks DOAB: description of the publication |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Chapter 48 In Vivo Bioluminescence Imaging to Assess Compound Efficacy Against Trypanosoma brucei
by: Ritchie, Ryan
Published: (2020) -
Chapter Cell Culture and Maintenance of the Evolutionary Forms of Trypanosoma cruzi for Studies of Parasitic Biology
by: Gonçalves, Moreno
Published: (2019) -
Parasites in the Tropic - A New Paradigm Shift
by: Suleyman Yazar
Published: (2017) -
Interaction of Trypanosoma cruzi with Host Cells
by: Wanderley De Souza
Published: (2014) -
G Protein-Coupled Receptor Kinases (GRKs) and Beta-Arrestins: New Insights into Disease Regulators
Published: (2020)