Chapter 14 Coupled Enzyme Activity and Thermal Shift Screening of the Maybridge Rule of 3 Fragment Library Against Trypanosoma brucei Choline Kinase; A Genetically Validated Drug Target

Chapter 14 Coupled Enzyme Activity and Thermal Shift Screening of the Maybridge Rule of 3 Fragment Library Against Trypanosoma brucei Choline Kinase; A Genetically Validated Drug Target

In this study we interrogate 630 compounds of the Maybridge Rule of 3 Fragment Library for compounds that interact with, and inhibit TbCK. The Maybridge Rule of 3 Fragment Library is a small collection of quantifiable diverse, pharmacophoric rich, chemical entities that comply with the following cri...

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Bibliografiska uppgifter
Huvudupphovsman: Denton, Helen (auth)
Övriga upphovsmän: Major, Louise L. (auth), Smith, Terry K. (auth)
Materialtyp: Bokavsnitt
Publicerad: InTechOpen 2013
Ämnen:
Pharmacology
pharmacology
toxicology
Assay
Enzyme
Molar concentration
Protein
Thermal shift assay
Trypanosoma brucei
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DOAB: description of the publication
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