Chapter 13 Targeting Tumor Perfusion and Oxygenation Modulates Hypoxia and Cancer Sensitivity to Radiotherapy and Systemic Therapies

Chapter 13 Targeting Tumor Perfusion and Oxygenation Modulates Hypoxia and Cancer Sensitivity to Radiotherapy and Systemic Therapies

Hypoxia, a partial pressure of oxygen (pO2) below physiological needs, is a limiting factor affecting the efficiency of radiotherapy. Indeed, the reaction of reactive oxygen species (ROS, produced by water radiolysis) with DNA is readily reversible unless oxygen stabilizes the DNA lesion. While no...

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Autor principal: Jordan, Bénédicte F. (auth)
Otros Autores: Sonveaux, Pierre (auth)
Formato: Capítulo de libro
Publicado: InTechOpen 2011
Materias:
Science: general issues
tumor
systematic therapies
hypoxia
radiotherapy
cancer sensitivity
Blood
Hemodynamics
Magnetic resonance imaging
Neoplasm
Oxygen
Perfusion
Radiation therapy
Vasodilation
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