Chapter 8 Signalling DNA Damage
During our lifetime, the genome is constantly being exposed to different types of damage caused either by exogenous sources (radiations and/or genotoxic compound) but also as byproducts of endogenous processes (reactive oxigen species during respiration, stalled forks during replication, eroded telo...
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InTechOpen
2012
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| 041 | 0 | |a English | |
| 042 | |a dc | ||
| 072 | 7 | |a PD |2 bicssc | |
| 100 | 1 | |a Lopez-Contreras, Andres Joaquin |4 auth | |
| 700 | 1 | |a Fernandez-Capetillo, Oscar |4 auth | |
| 700 | 1 | |a Joaquin, Andres |4 auth | |
| 700 | 1 | |a Fernandez-Capetillo, Oscar |4 auth | |
| 245 | 1 | 0 | |a Chapter 8 Signalling DNA Damage |
| 260 | |b InTechOpen |c 2012 | ||
| 506 | 0 | |a Open Access |2 star |f Unrestricted online access | |
| 520 | |a During our lifetime, the genome is constantly being exposed to different types of damage caused either by exogenous sources (radiations and/or genotoxic compound) but also as byproducts of endogenous processes (reactive oxigen species during respiration, stalled forks during replication, eroded telomeres, etc). From a structural point of view, there are many types of DNA damage including single or double strand breaks, base modifications and losses or base-pair mismatches. The amount of lesions that we face is enormous with estimates suggesting that each of our 1013 cells has to deal with around 10.000 lesions per day [1]. While the majority of these events are properly resolved by specialized mechanisms, a deficient response to DNA damage, and particularly to DSB, harbors a serious threat to human health [2]. DSB can be formed [1] following an exposure to ionizing radiation (X- or γ-rays) or clastogenic drugs; [2] endogenously, during DNA replication, or [3], as a consequence of reactive oxygen species (ROS) generated during oxidative metabolism. In addition, programmed DSB are used as repair intermediates during V(D)J and Class-Switch recombination (CSR) in lymphocytes [3], or during meiotic recombination [4]. Because of this, immunodeficiency and/or sterility problems are frequently associated with DDR-related pathologies. | ||
| 540 | |a Creative Commons |f https://creativecommons.org/licenses/by/3.0/ |2 cc |4 https://creativecommons.org/licenses/by/3.0/ | ||
| 546 | |a English | ||
| 650 | 7 | |a Science: general issues |2 bicssc | |
| 653 | |a dna damage | ||
| 653 | |a dna damage | ||
| 653 | |a Apoptosis | ||
| 653 | |a Ataxia telangiectasia and Rad3 related | ||
| 653 | |a ATM serine/threonine kinase | ||
| 653 | |a DNA repair | ||
| 653 | |a DNA-PKcs | ||
| 653 | |a Phosphorylation | ||
| 653 | |a Protein | ||
| 653 | |a Ubiquitin | ||
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| 856 | 4 | 0 | |a www.oapen.org |u https://directory.doabooks.org/handle/20.500.12854/33854 |7 0 |z DOAB: description of the publication |