Antimicrobial peptides and Complement - Maximising the inflammatory response
Antimicrobial peptides and complement are distinct components of the innate immune defence. While antimicrobial peptides, after cleavage of a preproprotein, have the ability to insert directly in non host membranes, complement requires a sequential enzymatic activation in the fluid phase in order to...
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| Format: | Book Chapter |
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Frontiers Media SA
2015
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| Online Access: | Get Fullteks DOAB: description of the publication |
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| LEADER | 02337naaaa2200301uu 4500 | ||
|---|---|---|---|
| 001 | doab_20_500_12854_40966 | ||
| 005 | 20210211 | ||
| 020 | |a 978-2-88919-737-8 | ||
| 020 | |a 9782889197378 | ||
| 024 | 7 | |a 10.3389/978-2-88919-737-8 |c doi | |
| 041 | 0 | |a English | |
| 042 | |a dc | ||
| 100 | 1 | |a Cordula M. Stover |4 auth | |
| 245 | 1 | 0 | |a Antimicrobial peptides and Complement - Maximising the inflammatory response |
| 260 | |b Frontiers Media SA |c 2015 | ||
| 300 | |a 1 electronic resource (157 p.) | ||
| 506 | 0 | |a Open Access |2 star |f Unrestricted online access | |
| 520 | |a Antimicrobial peptides and complement are distinct components of the innate immune defence. While antimicrobial peptides, after cleavage of a preproprotein, have the ability to insert directly in non host membranes, complement requires a sequential enzymatic activation in the fluid phase in order to produce a transmembrane membrane attack complex. Its insertion is controlled by membrane bound regulators. Deficiencies are described for both effectors and relate to increased susceptibility of infection. In addition, however, antimicrobial peptides and complement each influence the activity of inflammatory cells as recent data in the respective research areas shows. This series of articles draws together for the entities of antimicrobial peptides and complement a balance of contributions in the areas of evolution, roles, functions and preclinical applications. By comparing and contrasting antimicrobial peptides and complement, greater cross-disciplinary appreciation will be derived for their individual and overlapping spectra of activity, circumstances of activation and their general ability to more completely inform the inflammatory and cellular response. | ||
| 540 | |a Creative Commons |f https://creativecommons.org/licenses/by/4.0/ |2 cc |4 https://creativecommons.org/licenses/by/4.0/ | ||
| 546 | |a English | ||
| 653 | |a Disease | ||
| 653 | |a regulation | ||
| 653 | |a Health | ||
| 653 | |a system-specific | ||
| 653 | |a complement | ||
| 653 | |a antimicrobial peptides | ||
| 856 | 4 | 0 | |a www.oapen.org |u http://journal.frontiersin.org/researchtopic/2912/antimicrobial-peptides-and-complement---maximising-the-inflammatory-response |7 0 |z Get Fullteks |
| 856 | 4 | 0 | |a www.oapen.org |u https://directory.doabooks.org/handle/20.500.12854/40966 |7 0 |z DOAB: description of the publication |