Application of Antigen Cross-Presentation Research into Patient Care
The activation of adaptive immune responses requires the processing and presentation of protein antigens to lymphocytes. Especially dendritic cells are effective at display of antigen-derived peptides in the form of immunogenic peptide/MHC complexes to CD4 and CD8-positive T cells, and can stimulate...
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| Format: | Book Chapter |
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Frontiers Media SA
2017
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| Online Access: | Get Fullteks DOAB: description of the publication |
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| LEADER | 02383naaaa2200289uu 4500 | ||
|---|---|---|---|
| 001 | doab_20_500_12854_41040 | ||
| 005 | 20210211 | ||
| 020 | |a 978-2-88945-191-3 | ||
| 020 | |a 9782889451913 | ||
| 024 | 7 | |a 10.3389/978-2-88945-191-3 |c doi | |
| 041 | 0 | |a English | |
| 042 | |a dc | ||
| 100 | 1 | |a Marianne Boes |4 auth | |
| 245 | 1 | 0 | |a Application of Antigen Cross-Presentation Research into Patient Care |
| 260 | |b Frontiers Media SA |c 2017 | ||
| 300 | |a 1 electronic resource (124 p.) | ||
| 506 | 0 | |a Open Access |2 star |f Unrestricted online access | |
| 520 | |a The activation of adaptive immune responses requires the processing and presentation of protein antigens to lymphocytes. Especially dendritic cells are effective at display of antigen-derived peptides in the form of immunogenic peptide/MHC complexes to CD4 and CD8-positive T cells, and can stimulate even naive T cells to clonally expand. During the last 40 years, mechanisms that facilitate antigen processing and presentation were clarified, mostly from work in cell lines and mouse models. From mouse-based work, it is now clear that dendritic cells represent a collection of specialized cell subsets that are particularly well endowed to stimulate antigen transport to distinct tissue locations, to transfer antigens between cellular subsets or to trigger T cell responses. Dendritic cell subsets hold great promise for therapeutic application, for example as dendritic cell-based vaccines to bolster immune responses against viruses or malignant growths. Hurdles remain that preclude the efficient application of high quality pre-clinical research into standardized patient care. In this research topic, efforts in dendritic cell research and dendritic cell-based vaccines are discussed, from both pre-clinical and application points of view. | ||
| 540 | |a Creative Commons |f https://creativecommons.org/licenses/by/4.0/ |2 cc |4 https://creativecommons.org/licenses/by/4.0/ | ||
| 546 | |a English | ||
| 653 | |a clinical translation | ||
| 653 | |a cross-presentation | ||
| 653 | |a Vaccination | ||
| 653 | |a Immunotherapy | ||
| 653 | |a dendritic cell | ||
| 856 | 4 | 0 | |a www.oapen.org |u http://journal.frontiersin.org/researchtopic/1985/application-of-antigen-cross-presentation-research-into-patient-care |7 0 |z Get Fullteks |
| 856 | 4 | 0 | |a www.oapen.org |u https://directory.doabooks.org/handle/20.500.12854/41040 |7 0 |z DOAB: description of the publication |