Bioengineering Liver Transplantation

The aim of this Special Issue is to review, understand, and evaluate new and exciting opportunities from the field on regenerative medicine, biomaterials, and stem cell research for the bioengineering of human liver grafts that can be applied for transplantation and personalized treatment of end-sta...

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Auteur principal: Spee, Bart (auth)
Autres auteurs: Van der Laan, Luc J.W (auth), Verstegen, Monique M. A. (auth)
Format: Chapitre de livre
Publié: MDPI - Multidisciplinary Digital Publishing Institute 2019
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Accès en ligne:Get Fullteks
DOAB: description of the publication
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100 1 |a Spee, Bart  |4 auth 
700 1 |a Van der Laan, Luc J.W.  |4 auth 
700 1 |a Verstegen, Monique M. A.  |4 auth 
245 1 0 |a Bioengineering Liver Transplantation 
260 |b MDPI - Multidisciplinary Digital Publishing Institute  |c 2019 
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520 |a The aim of this Special Issue is to review, understand, and evaluate new and exciting opportunities from the field on regenerative medicine, biomaterials, and stem cell research for the bioengineering of human liver grafts that can be applied for transplantation and personalized treatment of end-stage liver disease.The development of culture conditions for long-term expansion of LGR5+ intestinal stem cells as crypt-villus structures demonstrated the feasibility of deriving complex, organ-like structures in vitro from primary adult tissues, including the liver. Moreover, human pluripotent stem cells (hPSCs) can be applied to generate functionally maturated liver and bile duct epithelial cells.In this Special Issue, we welcome reviews and original papers focussing on hepatic cell sources, including adult hepatic stem cells, organoids, fetal and induced pluripotent stem cells, and primary cells (i.e., hepatocytes, cholangiocytes, and endothelial cells) and how these cells can be applied in tissue engineering strategies to generate implantable and personalized liver grafts. Potential topics include, but are not limited to, the following: liver tissue engineering, liver regeneration, graft repair, liver stem cells and organoids, bio-scaffolds, and 3D printing.We invite you to contribute original research papers, as well as comprehensive reviews, aligned with these themes, to advance and improve the actual state-of-the-art in liver bioengineering and providing new opportunities for the imminent medical problem of organ and tissue shortage for transplantation. 
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653 |a n/a 
653 |a tissue engineering 
653 |a regenerative medicine 
653 |a liver tissue bioengineering 
653 |a additive manufacturing 
653 |a copper toxicosis 
653 |a hepatobiliary stent 
653 |a reconditioning 
653 |a medical device 
653 |a liver regeneration 
653 |a Wilson Disease 
653 |a stem cells 
653 |a preclinical large animal model 
653 |a liver 
653 |a stem cell transplantation 
653 |a liver bioreactors 
653 |a personalized medicine 
653 |a direct printing 
653 |a hydrogel 
653 |a 3D structuring 
653 |a oxygen persufflation 
653 |a end-stage liver diseases 
653 |a 3D printing 
653 |a liver transplantation 
653 |a bioengineered organ 
653 |a randomized controlled trail 
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