Brain Injury as a Neurodegenerative Disorder
It has been long assumed that following the resolution of acute injuries, traumatic brain injury represents a stable neural entity. However, there is growing evidence that a single moderate-severe brain injury may instead trigger an ongoing deteriorative process that commences sub-acutely, and occur...
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Format: | Book Chapter |
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Frontiers Media SA
2017
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Online Access: | Get Fullteks DOAB: description of the publication |
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LEADER | 02394naaaa2200289uu 4500 | ||
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001 | doab_20_500_12854_42415 | ||
005 | 20210211 | ||
020 | |a 978-2-88919-901-3 | ||
020 | |a 9782889199013 | ||
024 | 7 | |a 10.3389/978-2-88919-901-3 |c doi | |
041 | 0 | |a English | |
042 | |a dc | ||
100 | 1 | |a Robin E.A. Green |4 auth | |
245 | 1 | 0 | |a Brain Injury as a Neurodegenerative Disorder |
260 | |b Frontiers Media SA |c 2017 | ||
300 | |a 1 electronic resource (102 p.) | ||
506 | 0 | |a Open Access |2 star |f Unrestricted online access | |
520 | |a It has been long assumed that following the resolution of acute injuries, traumatic brain injury represents a stable neural entity. However, there is growing evidence that a single moderate-severe brain injury may instead trigger an ongoing deteriorative process that commences sub-acutely, and occurs regardless of age. For scientists and clinicians, it is critical to examine this body of evidence and to explore its implications. Do the findings represent a neurodegenerative process or can they be alternatively explained? What are the neural, behavioural and functional characteristics of this progressive deterioration? Such information is needed to develop treatments to prevent or mitigate decline, and to inform the clinical care of brain injured patients. Research and clinical practice are influenced by the assumption that moderate-severe TBI is non-progressive, with few studies exploring treatments to prevent progression, and rehabilitation typically concentrated in the early stages of injury. Brain injuries can never be fully prevented. However, understanding that such progressive deterioration occurs opens a novel area of research - prevention of secondary decline - offering new possibilities for the improvement of long-term outcomes in people with traumatic brain injury. | ||
540 | |a Creative Commons |f https://creativecommons.org/licenses/by/4.0/ |2 cc |4 https://creativecommons.org/licenses/by/4.0/ | ||
546 | |a English | ||
653 | |a Atrophy | ||
653 | |a chronic TBI | ||
653 | |a neurodegeneration | ||
653 | |a moderate-severe TBI | ||
653 | |a chronic traumatic encephalopathy | ||
856 | 4 | 0 | |a www.oapen.org |u http://journal.frontiersin.org/researchtopic/304/brain-injury-as-a-neurodegenerative-disorder |7 0 |z Get Fullteks |
856 | 4 | 0 | |a www.oapen.org |u https://directory.doabooks.org/handle/20.500.12854/42415 |7 0 |z DOAB: description of the publication |