Carbonic Anhydrases and Metabolism

Carbonic anhydrases (CAs; EC 4.2.1.1) are metalloenzymes present in all kingdoms of life, as they equilibrate the reaction between three simple but essential chemical species: CO2, bicarbonate, and protons. Discovered more than 80 years ago, in 1933, these enzymes have been extensively investigated...

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Bibliografski detalji
Glavni autor:	Supuran, Claudiu T. (auth)
Format:	Poglavlje knjige
Izdano:	MDPI - Multidisciplinary Digital Publishing Institute 2019
Teme:	antibiotic inhibitors glaucoma metabolic role inhibitor engineered bacteria carbonic anhydrase inhibitors drug discovery enzyme inhibition V-ATPases photosynthesis Chlamydomonas reinhardtii metalloenzymes CO2 capture bicarbonate benzamide hypoxia antibody model alga cancer therapeutics CA gene family resistance isoforms IX and XII cancer metabolism MMP14 carbonic anhydrase IX carboxylation bacterial enzymes antitumor agent metabolism activator bacterial carbonic anhydrases amine amino acid pH regulation proton pump inhibitors pathogens sulfonamide metastasis hypoxic tumor carbonic anhydrase pH carbonic anhydrases protozoan integrin Entamoeba histolytica tumors human isoform acidity invasion radiation tumor carbonic anhydrase XII transporter migration cancer tumor microenvironment
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Carbonic Anhydrases and Metabolism

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