G-quadruplex and Microorganisms
G-quadruplexes (G4s) are nucleic acids secondary structures that form in DNA or RNA guanine (G)-rich strands. In recent years, the presence of G4s in microorganisms has attracted increasing interest. In prokaryotes, G4 sequences have been reported in several human pathogens. Bacterial enzymes able t...
Saved in:
| Main Author: | |
|---|---|
| Format: | Book Chapter |
| Published: |
MDPI - Multidisciplinary Digital Publishing Institute
2019
|
| Subjects: | |
| Online Access: | Get Fullteks DOAB: description of the publication |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| LEADER | 03701naaaa2200829uu 4500 | ||
|---|---|---|---|
| 001 | doab_20_500_12854_48248 | ||
| 005 | 20210211 | ||
| 020 | |a books978-3-03921-244-6 | ||
| 020 | |a 9783039212439 | ||
| 020 | |a 9783039212446 | ||
| 024 | 7 | |a 10.3390/books978-3-03921-244-6 |c doi | |
| 041 | 0 | |a English | |
| 042 | |a dc | ||
| 100 | 1 | |a Richter, Sara N. |4 auth | |
| 245 | 1 | 0 | |a G-quadruplex and Microorganisms |
| 260 | |b MDPI - Multidisciplinary Digital Publishing Institute |c 2019 | ||
| 300 | |a 1 electronic resource (208 p.) | ||
| 506 | 0 | |a Open Access |2 star |f Unrestricted online access | |
| 520 | |a G-quadruplexes (G4s) are nucleic acids secondary structures that form in DNA or RNA guanine (G)-rich strands. In recent years, the presence of G4s in microorganisms has attracted increasing interest. In prokaryotes, G4 sequences have been reported in several human pathogens. Bacterial enzymes able to process G4s have been identified. In viruses, G4s have been suggested to be involved in key steps of the viral life cycle: They have been associated with the human immunodeficiency virus (HIV), herpes simplex virus 1 (HSV-1), human papilloma virus, swine pseudorabies virus, and other viruses' genomes. New evidence shows the presence of G4s in parasitic protozoa, such as the causative agent of malaria. G4 binding proteins and mRNA G4s have been implicated in the regulation of microorganisms' genome replication and translation. G4 ligands have been developed and tested both as tools to study the complexity of G4-mediated mechanisms in the viral life cycle and as therapeutic agents. Moreover, new techniques to study G4 folding and their interactions with proteins have been developed. This Special Issue will focus on G4s present in microorganisms, addressing all the above aspects. | ||
| 540 | |a Creative Commons |f https://creativecommons.org/licenses/by-nc-nd/4.0/ |2 cc |4 https://creativecommons.org/licenses/by-nc-nd/4.0/ | ||
| 546 | |a English | ||
| 653 | |a bacteria | ||
| 653 | |a folding | ||
| 653 | |a co-translational refolding | ||
| 653 | |a RecQ helicase | ||
| 653 | |a regulatory element | ||
| 653 | |a conformational dynamics | ||
| 653 | |a G4Hunter | ||
| 653 | |a NDPK | ||
| 653 | |a fluorescence | ||
| 653 | |a pseudorabies virus | ||
| 653 | |a Epstein-Barr virus (EBV) | ||
| 653 | |a structure-activity relationship | ||
| 653 | |a PhenDC3 | ||
| 653 | |a eukaryotic hosts | ||
| 653 | |a Herpesvirus | ||
| 653 | |a translation suppression | ||
| 653 | |a turn-on ligands | ||
| 653 | |a co-transcriptional folding | ||
| 653 | |a Herpesviridae | ||
| 653 | |a G-quadruplex | ||
| 653 | |a nucleoside diphosphate kinase | ||
| 653 | |a nucleic acids | ||
| 653 | |a nucleic acids conformation | ||
| 653 | |a bioinformatics | ||
| 653 | |a protein-DNA interaction | ||
| 653 | |a aptamers | ||
| 653 | |a deinococcus | ||
| 653 | |a Alphaherpesvirinae | ||
| 653 | |a EBNA1 | ||
| 653 | |a G4 | ||
| 653 | |a virus | ||
| 653 | |a human papillomaviruses | ||
| 653 | |a S. cerevisiae | ||
| 653 | |a genome stability | ||
| 653 | |a G-quadruplexes | ||
| 653 | |a metastable structure | ||
| 653 | |a genome evolution | ||
| 653 | |a pyridostatin | ||
| 653 | |a alphaherpesviruses | ||
| 653 | |a structure | ||
| 653 | |a protozoa | ||
| 653 | |a genome | ||
| 653 | |a G-quadruplex ligand | ||
| 653 | |a NMR | ||
| 653 | |a microbes | ||
| 653 | |a DNA | ||
| 653 | |a protein-mRNA interactions | ||
| 653 | |a G-quadruplex formation | ||
| 653 | |a immediate early promoters | ||
| 856 | 4 | 0 | |a www.oapen.org |u https://mdpi.com/books/pdfview/book/1495 |7 0 |z Get Fullteks |
| 856 | 4 | 0 | |a www.oapen.org |u https://directory.doabooks.org/handle/20.500.12854/48248 |7 0 |z DOAB: description of the publication |