Inhibiting PARP as a Strategic Target in Cancer

Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell's ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types...

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Bibliographic Details
Main Author: Kristin Zorn (auth)
Other Authors: Christina Annunziata (auth)
Format: Book Chapter
Published: Frontiers Media SA 2016
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