Marine Glycosides

In recent years, there has been a steady increase in the publication of papers on the chemistry, biology, and potential clinical uses of marine glycosides. Indeed, more than half of the papers published in this field are less than a decade old. Glycosides have been isolated from species as diverse a...

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Bibliographic Details
Main Author: Adrian, Thomas E (auth)
Other Authors: Sarabia, Francisco (auth), Cheng-Sanchez, Ivan (auth)
Format: Book Chapter
Published: MDPI - Multidisciplinary Digital Publishing Institute 2019
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Online Access:Get Fullteks
DOAB: description of the publication
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020 |a books978-3-03897-903-6 
020 |a 9783038979036 
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024 7 |a 10.3390/books978-3-03897-903-6  |c doi 
041 0 |a English 
042 |a dc 
100 1 |a Adrian, Thomas E  |4 auth 
700 1 |a Sarabia, Francisco  |4 auth 
700 1 |a Cheng-Sanchez, Ivan  |4 auth 
245 1 0 |a Marine Glycosides 
260 |b MDPI - Multidisciplinary Digital Publishing Institute  |c 2019 
300 |a 1 electronic resource (264 p.) 
506 0 |a Open Access  |2 star  |f Unrestricted online access 
520 |a In recent years, there has been a steady increase in the publication of papers on the chemistry, biology, and potential clinical uses of marine glycosides. Indeed, more than half of the papers published in this field are less than a decade old. Glycosides have been isolated from species as diverse as algae, fungi, anthozoans, and echinoderms. Even fish of the genus Pardachirus produce glycosides, which they use as shark repellents.<false,>The major interest in these compounds as potential drugs stems from their broad spectrum of biological effects. They have been shown to have antimicrobial, antifungal, anti-inflammatory, immune modulatory, and anticancer effects. The anticancer effects of marine glycosides include cell cycle suppression, the induction of apoptosis, and the inhibition of migration, invasion, and metastasis, as well as antiangiogenesis. Marine glycosides influence membrane permeability and have been shown to influence membrane transport at the molecular level through effects on transport carriers and pumps, as well as effects on ligand-gated and voltage-gated channels. Various marine glycosides have been shown to activate sphingomyelinase and ceramide synthesis, to inhibit topoisomerase activity, receptor tyrosine kinase activity, and multidrug resistance protein activity, and to antagonize eicosanoid receptors.<false,>This Special Issue covers the entire scope of marine organism-derived glycosides that are of potential value as pharmaceutical agents or leads. These include, but are not limited to, tetracyclic triterpene glycosides, other triterpene glycosides, steroid glycosides, and glycosides of non-isoprenoid aglycones. 
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546 |a English 
653 |a leukemia 
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653 |a antitumor 
653 |a deep-sea 
653 |a antibacterial 
653 |a anticoagulant 
653 |a saquayamycin 
653 |a marine invertebrate 
653 |a triterpene glycoside 
653 |a glycosides 
653 |a carbohydrate 
653 |a polyhydroxysteroidal glycoside 
653 |a glycosphingolipids 
653 |a triterpene glycosides 
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653 |a magnumosides 
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653 |a nonholostane 
653 |a Eupentacta fraudatrix 
653 |a angucycline 
653 |a urdamycin 
653 |a marine ginseng 
653 |a sponge 
653 |a antimicrobial 
653 |a holostane 
653 |a apoptosis 
653 |a cholesterol sulfate 
653 |a SMMC-7721 
653 |a metastases 
653 |a Culcita novaeguineae 
653 |a natural products 
653 |a marine organisms 
653 |a liquid chromatography-tandem mass spectrometry 
653 |a anti-inflammatory 
653 |a tumor growth 
653 |a mass spectrometry 
653 |a ESI 
653 |a total synthesis 
653 |a starfish 
653 |a sea cucumber 
653 |a cytotoxic 
653 |a cytotoxicity 
653 |a saponins 
653 |a Neothyonidium magnum 
653 |a glycolipids 
653 |a glycoglycerolipids 
653 |a Conus pulicarius 
653 |a MALDI 
653 |a Streptomyces 
653 |a glycoside 
653 |a radioactive irradiation 
653 |a frondoside A 
653 |a LC-MS 
653 |a invasion 
653 |a Holothuroidea 
653 |a saponin 
653 |a bioactive compounds 
653 |a cancer 
653 |a structure elucidation 
653 |a mangrove-derived Streptomyces 
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