Mechanisms of antibiotic resistance

Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased tr...

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Bibliographic Details
Main Author: Marcelo Tolmasky (auth)
Other Authors: Jun Lin (auth), Marilyn C. Roberts (auth), Kunihiko Nishino (auth), Lixin Zhang (auth), Rustam I. Aminov (auth)
Format: Book Chapter
Published: Frontiers Media SA 2015
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Online Access:Get Fullteks
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041 0 |a English 
042 |a dc 
100 1 |a Marcelo Tolmasky  |4 auth 
700 1 |a Jun Lin  |4 auth 
700 1 |a Marilyn C. Roberts  |4 auth 
700 1 |a Kunihiko Nishino  |4 auth 
700 1 |a Lixin Zhang  |4 auth 
700 1 |a Rustam I. Aminov  |4 auth 
245 1 0 |a Mechanisms of antibiotic resistance 
260 |b Frontiers Media SA  |c 2015 
300 |a 1 electronic resource (224 p.) 
506 0 |a Open Access  |2 star  |f Unrestricted online access 
520 |a Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://ec.europa.eu/dgs/health_consumer/docs/road-map-amr_en.pdf: http://www.who.int/drugresistance/amr_global_action_plan/en/; http://www.whitehouse.gov/sites/default/files/docs/carb_national_strategy.pdf). Understanding the mechanisms by which bacteria successfully defend themselves against the antibiotic assault represent the main theme of this eBook published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy. The articles in the eBook update the reader on various aspects and mechanisms of antibiotic resistance. A better understanding of these mechanisms should facilitate the development of means to potentiate the efficacy and increase the lifespan of antibiotics while minimizing the emergence of antibiotic resistance among pathogens. 
540 |a Creative Commons  |f https://creativecommons.org/licenses/by/4.0/  |2 cc  |4 https://creativecommons.org/licenses/by/4.0/ 
546 |a English 
653 |a Metagenomics 
653 |a Antibiotic resistance mechanisms 
653 |a combination therapy 
653 |a antibiotics 
653 |a antibiotic resistance reservoirs 
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