Metabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions
Proliferating cells must adapt their metabolism to fulfill the increased requirements for energy demands and biosynthetic intermediates. This adaptation is particularly relevant in cancer, where sustained rapid proliferation combined with the harsh conditions of the tumor microenvironment represent...
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| Format: | Book Chapter |
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Frontiers Media SA
2018
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| Online Access: | Get Fullteks DOAB: description of the publication |
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| LEADER | 02219naaaa2200325uu 4500 | ||
|---|---|---|---|
| 001 | doab_20_500_12854_53224 | ||
| 005 | 20210211 | ||
| 020 | |a 978-2-88945-484-6 | ||
| 020 | |a 9782889454846 | ||
| 024 | 7 | |a 10.3389/978-2-88945-484-6 |c doi | |
| 041 | 0 | |a English | |
| 042 | |a dc | ||
| 100 | 1 | |a Lluis Fajas |4 auth | |
| 700 | 1 | |a Albert Giralt |4 auth | |
| 245 | 1 | 0 | |a Metabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions |
| 260 | |b Frontiers Media SA |c 2018 | ||
| 300 | |a 1 electronic resource (70 p.) | ||
| 506 | 0 | |a Open Access |2 star |f Unrestricted online access | |
| 520 | |a Proliferating cells must adapt their metabolism to fulfill the increased requirements for energy demands and biosynthetic intermediates. This adaptation is particularly relevant in cancer, where sustained rapid proliferation combined with the harsh conditions of the tumor microenvironment represent a major metabolic challenge. Noteworthy, metabolic reprogramming is now considered one of the hallmarks of cancer. However, the one size fits all rarely applies to the metabolic rewiring occurring in cancer cells, which ultimately depends on the combination of several factors such as the tumor's origin, the specific genetic alterations and the surrounding microenvironment. In the present Research Topic, we compile a series of articles that discuss different metabolic adaptations that proliferating cells undergo to sustain growth and division, as well as the potential therapeutic window to treat certain pathologies, with a special focus on cancer. | ||
| 540 | |a Creative Commons |f https://creativecommons.org/licenses/by/4.0/ |2 cc |4 https://creativecommons.org/licenses/by/4.0/ | ||
| 546 | |a English | ||
| 653 | |a cancer metabolism | ||
| 653 | |a proliferation | ||
| 653 | |a mitochondria | ||
| 653 | |a lipogenesis | ||
| 653 | |a metabolic adaptation | ||
| 653 | |a obesity | ||
| 653 | |a Warburg effect | ||
| 856 | 4 | 0 | |a www.oapen.org |u https://www.frontiersin.org/research-topics/4124/metabolic-adaptation-to-cell-growth-and-proliferation-in-normal-and-pathological-conditions |7 0 |z Get Fullteks |
| 856 | 4 | 0 | |a www.oapen.org |u https://directory.doabooks.org/handle/20.500.12854/53224 |7 0 |z DOAB: description of the publication |