Molecular mechanisms for reprogramming hippocampal development and function by early-life stress

The early postnatal period is a crucial stage for hippocampal development. During this critical period, the neonatal hippocampus is highly sensitive to the detrimental consequences of adverse environmental factors. Extensive clinical and preclinical evidence has shown that traumatic events early in...

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Main Author: Mathias V. Schmidt (auth)
Other Authors: Xiao-Dong Wang (auth)
Format: Book Chapter
Published: Frontiers Media SA 2016
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Online Access:Get Fullteks
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001 doab_20_500_12854_53848
005 20210211
020 |a 978-2-88919-806-1 
020 |a 9782889198061 
024 7 |a 10.3389/978-2-88919-806-1  |c doi 
041 0 |a English 
042 |a dc 
100 1 |a Mathias V. Schmidt  |4 auth 
700 1 |a Xiao-Dong Wang  |4 auth 
245 1 0 |a Molecular mechanisms for reprogramming hippocampal development and function by early-life stress 
260 |b Frontiers Media SA  |c 2016 
300 |a 1 electronic resource (100 p.) 
506 0 |a Open Access  |2 star  |f Unrestricted online access 
520 |a The early postnatal period is a crucial stage for hippocampal development. During this critical period, the neonatal hippocampus is highly sensitive to the detrimental consequences of adverse environmental factors. Extensive clinical and preclinical evidence has shown that traumatic events early in life have profound and persistent effects on hippocampal function and behavior. This research topic focuses on the acute and lasting effects of early-life stress on various developmental processes in the hippocampus, and aims to uncover the molecules that are responsible for early-life stress-programmed effects and underlie resilience or vulnerability to stress-related neuropsychiatric disorders later in life. We hope the articles in this research topic will provide novel insights and stimulate future studies on the mechanisms of early-life stress and brain development. 
540 |a Creative Commons  |f https://creativecommons.org/licenses/by/4.0/  |2 cc  |4 https://creativecommons.org/licenses/by/4.0/ 
546 |a English 
653 |a development 
653 |a molecular mechanism 
653 |a early-life stress 
653 |a plasticity 
653 |a Hippocampus 
653 |a psychiatric disorders 
856 4 0 |a www.oapen.org  |u http://journal.frontiersin.org/researchtopic/1935/molecular-mechanisms-for-reprogramming-hippocampal-development-and-function-by-early-life-stress  |7 0  |z Get Fullteks 
856 4 0 |a www.oapen.org  |u https://directory.doabooks.org/handle/20.500.12854/53848  |7 0  |z DOAB: description of the publication