Molecular Organization of Membranes: Where Biology Meets Biophysics

Biological membranes protect cells and organelles from the surrounding environment, but serve also as organising platforms for physiological processes such as cell signalling. The hydrophobic core of membranes is composed of lipids and proteins influencing each other. Local membrane composition and...

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Main Author: Marek Cebecauer (auth)
Other Authors: David Holowka (auth)
Format: Book Chapter
Published: Frontiers Media SA 2018
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Online Access:Get Fullteks
DOAB: description of the publication
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020 |a 978-2-88945-409-9 
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041 0 |a English 
042 |a dc 
100 1 |a Marek Cebecauer  |4 auth 
700 1 |a David Holowka  |4 auth 
245 1 0 |a Molecular Organization of Membranes: Where Biology Meets Biophysics 
260 |b Frontiers Media SA  |c 2018 
300 |a 1 electronic resource (150 p.) 
506 0 |a Open Access  |2 star  |f Unrestricted online access 
520 |a Biological membranes protect cells and organelles from the surrounding environment, but serve also as organising platforms for physiological processes such as cell signalling. The hydrophobic core of membranes is composed of lipids and proteins influencing each other. Local membrane composition and properties define its molecular organisation and, in this way, regulate the function of all associated molecules. Therefore, studying interactions of components, biophysical properties and overall membrane dynamics provides essential information on its function in the context of cell activities. Such knowledge can contribute to biomedical fields such as pharmacology, immunology, neurobiology and many others. The goal of the Research Topic entitled 'Molecular organisation of membranes: where biology meets biophysics' was to provide a comprehensive platform for publishing articles, reviews and opinions focused on membrane organisation and the forces behind its heterogeneous and dynamic structure. We collected 11 works which cover topics as diverse as general membrane organisation models, membrane trafficking and signalling regulation, biogenesis of caveolae, protein-lipid interactions and the importance of membrane-associated tetraspanins networks. The prevalent theme was the existence of membrane nanodomains. To this point, new emerging technologies are presented which own the power to bring a novel insight on how membrane nanodomains are formed and maintained and what is their function. We believe that the collection of works in this Research Topic brings forward some important questions which will stimulate further research in this difficult but exciting field. 
540 |a Creative Commons  |f https://creativecommons.org/licenses/by/4.0/  |2 cc  |4 https://creativecommons.org/licenses/by/4.0/ 
546 |a English 
653 |a Cell Membrane 
653 |a Caveolae 
653 |a Superresolution microscopy 
653 |a Nanodomains 
653 |a Membrane trafficking 
653 |a Membrane properties 
653 |a fluorescence microscopy 
653 |a Tetraspanins 
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856 4 0 |a www.oapen.org  |u https://directory.doabooks.org/handle/20.500.12854/53853  |7 0  |z DOAB: description of the publication