Pharmaceutical Crystals

Pharmaceutical Crystals

The crystalline state is the most commonly used essential solid active pharmaceutical ingredient (API). The characterization of pharmaceutical crystals encompasses many scientific disciplines, but the core is crystal structure analysis, which reveals the molecular structure of essential pharmaceutic...

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Bibliographic Details
Main Author: Uekusa, Hidehiro (auth)
Other Authors: Yonemochi, Etsuo (auth)
Format: Book Chapter
Published: MDPI - Multidisciplinary Digital Publishing Institute 2020
Subjects:
crystal structure analysis
n/a
famotidine
solution crystallization
salt optimization
structure determination from powder diffraction data
Hirshfeld surface analysis
DFT
molecular docking study
melting diagram
dehydration
hygroscopicity
HBV
Benzodioxole
pharmaceutical crystals
4-b]indol-4-one
pyrimidin-4(3H)-one
liquid assisted grinding
HOMO-LUMO
dissolution
cocrystal formation
Raman spectroscopy
carbamazepine
hydrogen bonding
3
ondansetron
physicochemical properties
solubility
succinic acid
cocrystal
adefovir dipivoxil
hepatitis B
polymorphs
hydrogen-bond-acceptance ability
DFT study
Nitrofurantoin-4-dimethylaminopyridine (NF-DMAP) salt
photostability
on-line monitoring
5-dihydro-4H-pyrimido[5
Imidazole
Semicarbazone
crystal habit
Crystal structure
solvent-mediated polymorphic transformation
ticagrelor
hydrate
pharmaceutical cocrystal
malonic acid
1H-indole
reactivity descriptors
famoxadone
crystal structure
dicarboxylic acid
hydrogen bond
saccharin
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Description
Summary:The crystalline state is the most commonly used essential solid active pharmaceutical ingredient (API). The characterization of pharmaceutical crystals encompasses many scientific disciplines, but the core is crystal structure analysis, which reveals the molecular structure of essential pharmaceutical compounds. Crystal structure analysis provides important structural information related to the API's wide range of physicochemical properties, such as solubility, stability, tablet performance, color, and hygroscopicity. This book entitled "Pharmaceutical Crystals"" focuses on the relationship between crystal structure and physicochemical properties. In particular, the new crystal structure of pharmaceutical compounds involving multi-component crystals, such as co-crystals, salts, and hydrates, and polymorph crystals are reported. Such crystal structures were investigated in the latest studies that combined morphology, spectroscopic, theoretical calculation, and thermal analysis with crystallographic study. This book highlights the importance of crystal structure information in many areas of pharmaceutical science and presents current trends in the structure-property study of pharmaceutical crystals. The Guest Editors of this book hope the readers enjoy a wide variety of recent studies on Pharmaceutical Crystals.
Physical Description:1 electronic resource (148 p.)
ISBN:books978-3-03928-713-0
9783039287123
9783039287130
Access:Open Access

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