PPARs in Cellular and Whole Body Energy Metabolism
At no other time in its history has humankind been as concerned about good health. Lifestyle habits are promoted as indispensable allies for the daily prevention against so-called metabolic diseases. Paradoxically, the world has never been so obese, while the beauty canons have never been so skinny!...
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| Format: | Book Chapter |
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MDPI - Multidisciplinary Digital Publishing Institute
2019
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| Online Access: | Get Fullteks DOAB: description of the publication |
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| LEADER | 02613naaaa2200325uu 4500 | ||
|---|---|---|---|
| 001 | doab_20_500_12854_56800 | ||
| 005 | 20210211 | ||
| 020 | |a books978-3-03897-462-8 | ||
| 020 | |a 9783038974628 | ||
| 020 | |a 9783038974611 | ||
| 024 | 7 | |a 10.3390/books978-3-03897-462-8 |c doi | |
| 041 | 0 | |a English | |
| 042 | |a dc | ||
| 100 | 1 | |a Walter Wahli (Ed.) |4 auth | |
| 700 | 1 | |a Rachel Tee (Ed.) |4 auth | |
| 245 | 1 | 0 | |a PPARs in Cellular and Whole Body Energy Metabolism |
| 260 | |b MDPI - Multidisciplinary Digital Publishing Institute |c 2019 | ||
| 300 | |a 1 electronic resource (582 p.) | ||
| 506 | 0 | |a Open Access |2 star |f Unrestricted online access | |
| 520 | |a At no other time in its history has humankind been as concerned about good health. Lifestyle habits are promoted as indispensable allies for the daily prevention against so-called metabolic diseases. Paradoxically, the world has never been so obese, while the beauty canons have never been so skinny! However, there is more to energy balance than alterations in body weight. In the 1990s, it was found that fatty acids not only function as fuel molecules only, but also serve as signaling molecules. They bind nuclear hormone receptors, the Peroxisome Proliferator-Activated Receptors, commonly referred to by the acronym PPARs. PPARs are transcription factors that directly control the expression of genes of metabolism, thereby impacting a multitude of pathways crucial for whole body physiology. PPARs are also activated by synthetic agonists, which are drugs used for lowering triglycerides and blood sugar. This book features articles that address tools for the identification of novel PPAR ligands, as well as the roles of the receptors in several organs, such as the brain, heart, liver, adipose tissue, gut, and muscle. As such, this book documents the multifaceted roles of these nuclear receptors that continue to attract significant attention, not least because of their still not fully realized potential to treat several health conditions. | ||
| 540 | |a Creative Commons |f https://creativecommons.org/licenses/by-nc-nd/4.0/ |2 cc |4 https://creativecommons.org/licenses/by-nc-nd/4.0/ | ||
| 546 | |a English | ||
| 653 | |a Ligand identification | ||
| 653 | |a Peroxisome Proliferator-Activated Receptors (PPARs) | ||
| 653 | |a Energy homeostasis | ||
| 653 | |a Metabolic diseases | ||
| 653 | |a Metabolic regulations | ||
| 653 | |a Tumor development | ||
| 856 | 4 | 0 | |a www.oapen.org |u https://www.mdpi.com/books/pdfview/book/1079 |7 0 |z Get Fullteks |
| 856 | 4 | 0 | |a www.oapen.org |u https://directory.doabooks.org/handle/20.500.12854/56800 |7 0 |z DOAB: description of the publication |