Preclinical and clinical issues in Alzheimer's disease drug research and development

Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by progressive cognitive dysfunction and memory loss, inability to perform the activities of daily living and mood disorders. According to the so-called "amyloid cascade hypothesis", amyloid-ß- peptide (Aß)...

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Main Author: Silvana Gaetani (auth)
Other Authors: Cesare Mancuso (auth)
Format: Book Chapter
Published: Frontiers Media SA 2015
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