Recent Progress in Solid Dispersion Technology

Amorphous solid dispersion (ASD) is a powerful formulation technology to improve oral absorption of poorly soluble drugs. Despite their being in existence for more than half a century, controlling ASD performance is still regarded as difficult because of ASD's natural non-equilibrium. However,...

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Hlavní autor:	Kawakami, Kohsaku (auth)
Médium:	Kapitola
Vydáno:	MDPI - Multidisciplinary Digital Publishing Institute 2019
Témata:	thermodynamic modeling molecular dynamics simulation poorly soluble drugs amorphous solid dispersions dissolution enhancement crystallization tendency continuous processing stability milling granulation thermal analysis amorphous ball milling pharmaceutical glass dissolution rebamipide poloxamer classification polyelectrolytes amorphisation self-assembly dissolution rate miscibility bioavailability solubility evaporation mesoporous polyelectrolyte excipient matrix polymer bicaludamide phase diagram Weibull dissolution model spectroscopic techniques anticancer drugs manufacturing methods nucleation molecular complex nanoaggregates enrofloxacin accelerated stability test solubility enhancement amorphous solid dispersion tadalafil process development amorphous polymeric salt Wood's apparatus hot melt extrusion solid dispersions intrinsic dissolution rate solid dispersion interaction crystallization spray drying characterization ciprofloxacin
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Recent Progress in Solid Dispersion Technology

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