Recent Progress in Solid Dispersion Technology

Recent Progress in Solid Dispersion Technology

Amorphous solid dispersion (ASD) is a powerful formulation technology to improve oral absorption of poorly soluble drugs. Despite their being in existence for more than half a century, controlling ASD performance is still regarded as difficult because of ASD's natural non-equilibrium. However,...

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Autor Principal: Kawakami, Kohsaku (auth)
Formato: Capítulo de libro
Publicado: MDPI - Multidisciplinary Digital Publishing Institute 2019
Subjects:
thermodynamic modeling
molecular dynamics simulation
poorly soluble drugs
amorphous solid dispersions
dissolution enhancement
crystallization tendency
continuous processing
stability
milling
granulation
thermal analysis
amorphous
ball milling
pharmaceutical glass
dissolution
rebamipide
poloxamer
classification
polyelectrolytes
amorphisation
self-assembly
dissolution rate
miscibility
bioavailability
solubility
evaporation
mesoporous
polyelectrolyte excipient matrix
polymer
bicaludamide
phase diagram
Weibull dissolution model
spectroscopic techniques
anticancer drugs
manufacturing methods
nucleation
molecular complex
nanoaggregates
enrofloxacin
accelerated stability test
solubility enhancement
amorphous solid dispersion
tadalafil
process development
amorphous polymeric salt
Wood's apparatus
hot melt extrusion
solid dispersions
intrinsic dissolution rate
solid dispersion
interaction
crystallization
spray drying
characterization
ciprofloxacin
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