Single-Domain Antibodies: Biology, Engineering and Emerging Applications
Single-domain antibodies (sdAbs) represent the minimal antigen binding-competent form of the immunoglobulin domain and have unique properties and applications. SdAbs are naturally produced as the variable domains of the heavy chain-only antibodies of camelid ruminants and cartilaginous fishes, but c...
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| Format: | Book Chapter |
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Frontiers Media SA
2018
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| Online Access: | Get Fullteks DOAB: description of the publication |
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| LEADER | 02036naaaa2200301uu 4500 | ||
|---|---|---|---|
| 001 | doab_20_500_12854_59417 | ||
| 005 | 20210212 | ||
| 020 | |a 978-2-88945-432-7 | ||
| 020 | |a 9782889454327 | ||
| 024 | 7 | |a 10.3389/978-2-88945-432-7 |c doi | |
| 041 | 0 | |a English | |
| 042 | |a dc | ||
| 100 | 1 | |a Kevin A. Henry |4 auth | |
| 700 | 1 | |a C. Roger MacKenzie |4 auth | |
| 245 | 1 | 0 | |a Single-Domain Antibodies: Biology, Engineering and Emerging Applications |
| 260 | |b Frontiers Media SA |c 2018 | ||
| 300 | |a 1 electronic resource (338 p.) | ||
| 506 | 0 | |a Open Access |2 star |f Unrestricted online access | |
| 520 | |a Single-domain antibodies (sdAbs) represent the minimal antigen binding-competent form of the immunoglobulin domain and have unique properties and applications. SdAbs are naturally produced as the variable domains of the heavy chain-only antibodies of camelid ruminants and cartilaginous fishes, but can also be engineered synthetically from autonomous human or mouse VH or VL domains. The scope of this research topic and associated e-book covers current understanding and new developments in (i) the biology, immunology and immunogenetics of sdAbs in camelids and cartilaginous fishes, (ii) strategies for sdAb discovery, (iii) protein engineering approaches to increase the solubility, stability and antigen-binding affinity of sdAbs and (iv) specialized applications of sdAbs in areas such diagnostics, imaging and therapeutics. | ||
| 540 | |a Creative Commons |f https://creativecommons.org/licenses/by/4.0/ |2 cc |4 https://creativecommons.org/licenses/by/4.0/ | ||
| 546 | |a English | ||
| 653 | |a antibody engineering | ||
| 653 | |a antibody discovery | ||
| 653 | |a therapeutic antibody | ||
| 653 | |a diagnostic antibody | ||
| 653 | |a single-domain antibody | ||
| 856 | 4 | 0 | |a www.oapen.org |u https://www.frontiersin.org/research-topics/5098/single-domain-antibodies-biology-engineering-and-emerging-applications |7 0 |z Get Fullteks |
| 856 | 4 | 0 | |a www.oapen.org |u https://directory.doabooks.org/handle/20.500.12854/59417 |7 0 |z DOAB: description of the publication |