Novel Natural-based Biomolecules Discovery for Tackling Chronic Diseases

Natural-based biomolecules continuously play an important role in novel drug discovery for the treatment of chronic diseases. The development of natural peptide/protein-based, toxin-based, and antibody-based drugs can significantly improve the biomedical efficiency of disease-specific therapy. The f...

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Bibliographic Details
Other Authors: Kwok, Hang Fai (Editor)
Format: Book Chapter
Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
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245 1 0 |a Novel Natural-based Biomolecules Discovery for Tackling Chronic Diseases 
260 |a Basel, Switzerland  |b MDPI - Multidisciplinary Digital Publishing Institute  |c 2021 
300 |a 1 electronic resource (180 p.) 
506 0 |a Open Access  |2 star  |f Unrestricted online access 
520 |a Natural-based biomolecules continuously play an important role in novel drug discovery for the treatment of chronic diseases. The development of natural peptide/protein-based, toxin-based, and antibody-based drugs can significantly improve the biomedical efficiency of disease-specific therapy. The focus of this Special Issue of Biomolecules will be on the most recent advances related to novel peptides/proteins, antibodies, and toxins as forms of medicinal therapy. Recent advances in the discovery and development of these natural biomolecules for use in targeted therapy and immunotherapy against chronic diseases (e.g., cancer, diabetes, cardiovascular diseases, and rheumatoid arthritis) will be addressed. The discussion on using novel disease-specific proteins/peptides/toxins/antibodies along with currently available FDA-approved drugs as combinatorial treatments will also be encouraged in this context. Finally, an overview of some of the selected promising natural biomolecules that are potentially able to address the forthcoming challenges in this field will be included. Both research (in particular) and review articles proposing novelties or overviews, respectively, are welcome. 
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650 7 |a Humanities  |2 bicssc 
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653 |a molecular cloning 
653 |a antifungal 
653 |a drug design 
653 |a protease inhibitor 
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653 |a anticancer therapy 
653 |a lung cancer 
653 |a survivin 
653 |a apoptosis 
653 |a STAT3 
653 |a colorectal cancer 
653 |a orientin 
653 |a cell cycle arrest 
653 |a Bcl-2 family proteins 
653 |a Astragalus membranaceus 
653 |a insulin 
653 |a PI3K 
653 |a AKT 
653 |a PPARγ 
653 |a PDX-1 
653 |a Petasites japonicus 
653 |a Asteraceae 
653 |a lignan 
653 |a anti-inflammation 
653 |a NO 
653 |a PGE2 
653 |a iNOS 
653 |a COX-2 
653 |a molecular docking 
653 |a peptides 
653 |a kynurenines 
653 |a binding affinity 
653 |a μ-opioid receptor 
653 |a pharmacophore 
653 |a G-protein activation 
653 |a fucoidan 
653 |a PLGA 
653 |a docetaxel 
653 |a drug delivery system 
653 |a anticancer therapy/cancer treatment 
653 |a hIAPP 
653 |a amyloidogenesis 
653 |a insulin granules 
653 |a endoplasmic reticulum 
653 |a anionic lipids 
653 |a F23R variant 
653 |a β-sheet transitions 
653 |a β-cell cytotoxicity 
653 |a unfolded protein response 
653 |a pomegranate 
653 |a punicalagin 
653 |a tannins 
653 |a gingiva 
653 |a fibroblasts 
653 |a antioxidant 
653 |a wound healing 
653 |a branched-chain fatty acids 
653 |a Conidiobolus heterosporus 
653 |a peroxisome proliferator-activated receptor α 
653 |a lipid metabolism 
653 |a fatty acid oxidation 
653 |a hepatocyte 
653 |a n/a 
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