Human African Trypanosomiasis (Sleeping Sickness) : The Road to Elimination Revisited-Achievements and Remaining Challenges

Human African Trypanosomiasis (Sleeping Sickness) : The Road to Elimination Revisited-Achievements and Remaining Challenges

As it is a goal to eliminate human African trypanosomiasis (HAT; sleeping sickness) as a public health problem by 2020 and interrupt transmission by 2030, this is a good moment to reflect on what we have achieved, what we want to achieve, and what could get in our way. HAT has a reputation for spect...

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Detalhes bibliográficos
Outros Autores: Burri, Christian (Editor)
Formato: Capítulo de Livro
Publicado em: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
Assuntos:
Medicine
Epidemiology & medical statistics
(+)-spectaline
iso-6-spectaline
Trypanosoma brucei rhodesiense
autophagy
apoptosis
cross-talk
trypanosomosis
iron
transferrin
transferrin receptor
nutritional immunity
flagellar pocket
Human African Trypanosomiasis (HAT)
mydriasis
neurological signs
eradication
re-emergence
human African trypanosomiasis
treatment
melarsoprol
adverse event
encephalopathy
human leukocyte antigen
association study
disease elimination
disease eradication
frontline workers
DR Congo
mobile screening
qualitative methods
sequelae
serology
oligosymptomatic HAT
product development partnerships
research and development
medical innovation
donor policy
African trypanosomiasis
sleeping sickness
trypanosoma brucei
drugs
drug resistance
history
human Africa trypanosomiasis
fexinidazole
home-based treatment
patient-centred care
Uganda
elimination
T. b. gambiense
g-HAT
T. b. rhodesiense
r-HAT
neglected tropical diseases
Trypanosoma brucei
drug discovery
high-throughput screening
blood-brain barrier
brain permeability
pharmacology
phenotypic drug screening
Haemoparasites
animal reservoirs
Trypanosoma growth inhibitors
chemotherapy
pafuramidine
acoziborole
African sleeping sickness
development of treatment
suramin
medical history
political history
clinical research
health system strengthening
South Sudan
diagnosis
symptoms
treatment-seeking
case detection
embodiment
expertise
serendipity
CATT positive serological suspects
active follow-up strategy
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