Matrix Metalloproteinase

Zinc-dependent matrix metalloproteinases (MMPs) belong to metzincins that comprise not only 23 human MMPs but also other metalloproteinases, such as 21 human ADAMs (a disintegrin and metalloproteinase domain) and 19 secreted ADAMTSs (a disintegrin and metalloproteinase thrombospondin domain). The ma...

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Other Authors: Ågren, Magnus S. (Editor), Keller, Ulrich (Editor)
Format: Book Chapter
Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
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100 1 |a Ågren, Magnus S.  |4 edt 
700 1 |a Keller, Ulrich  |4 edt 
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700 1 |a Keller, Ulrich  |4 oth 
245 1 0 |a Matrix Metalloproteinase 
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300 |a 1 electronic resource (262 p.) 
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520 |a Zinc-dependent matrix metalloproteinases (MMPs) belong to metzincins that comprise not only 23 human MMPs but also other metalloproteinases, such as 21 human ADAMs (a disintegrin and metalloproteinase domain) and 19 secreted ADAMTSs (a disintegrin and metalloproteinase thrombospondin domain). The many setbacks from the clinical trials of broad-spectrum MMP inhibitors for cancer indications in the late 1990s emphasized the extreme complexity of the participation of these proteolytic enzymes in biology. This editorial mini-review summarizes the Special Issue, which includes four review articles and 10 original articles that highlight the versatile roles of MMPs, ADAMs, and ADAMTSs, in normal physiology as well as in neoplastic and destructive processes in tissue. In addition, we briefly discuss the unambiguous involvement of MMPs in wound healing. 
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650 7 |a Biology, life sciences  |2 bicssc 
653 |a hemagglutinin-B 
653 |a transwell co-cultures 
653 |a matrix metalloproteinases 
653 |a TNF-α 
653 |a matrix metalloproteinase 
653 |a peritoneal mesothelial cell 
653 |a gastric cancer 
653 |a metastatic dissemination 
653 |a MT4-MMP 
653 |a cancer 
653 |a diseases 
653 |a aggrecan 
653 |a aggrecanase 
653 |a ADAMTS 
653 |a cartilage 
653 |a arthritis 
653 |a MMP-2 
653 |a MMP-9 
653 |a inhibitor 
653 |a allodynia 
653 |a caspase-3 
653 |a neuropathic 
653 |a pain 
653 |a dorsal root ganglion 
653 |a spinal nerve ligation 
653 |a tuberculosis 
653 |a tuberculous meningitis 
653 |a HIV-TB-associated IRIS 
653 |a extracellular matrix breakdown 
653 |a adult 
653 |a pediatric 
653 |a lung 
653 |a central nervous system 
653 |a matrix-metalloproteinase 
653 |a monocytes 
653 |a inflammation 
653 |a phagocytosis 
653 |a apoptosis 
653 |a blood sampling 
653 |a anticoagulants 
653 |a high-molecular-weight heparin 
653 |a IL-16 
653 |a sICAM-1 
653 |a IL-8 
653 |a T cells 
653 |a a disintegrin and metalloproteinase 
653 |a EMMPRIN 
653 |a CD147 
653 |a ectodomain shedding 
653 |a MMPs 
653 |a PTMs 
653 |a glycosylation 
653 |a phosphorylation 
653 |a glycosaminoglycans 
653 |a interleukin 
653 |a IL-6 
653 |a IL-11 
653 |a trans-signaling 
653 |a metalloproteases 
653 |a ADAM 
653 |a MMP 
653 |a meprin 
653 |a matrix metalloproteinases (MMPs) 
653 |a protease 
653 |a signaling 
653 |a invasion 
653 |a chemokine 
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653 |a proteomics 
653 |a interferon 
653 |a Agkistrodon venom 
653 |a metalloproteinase 
653 |a fibrinogen 
653 |a antithrombotic 
653 |a metabolomics 
653 |a extracellular matrix 
653 |a cytokines 
653 |a proteinases 
653 |a interstitial collagens 
653 |a wound healing 
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