Fibroblast Growth Factor Receptor (FGFR) Signaling Pathway in Tumor

Fibroblast Growth Factor Receptor (FGFR) Signaling Pathway in Tumor

Fibroblast growth factor (FGF) signal transmission has an essential function in embryonic development and tissue repair, and is dysregulated in the vast majority of malignancies studied. The FGF signaling in the tumor cells is usually increased by autocrine and paracrine mechanisms and gives them a...

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Detalhes bibliográficos
Outros Autores: Holzmann, Klaus (Editor), Marian, Brigitte (Editor)
Formato: Capítulo de Livro
Publicado em: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
Assuntos:
Medicine
FGFR4
FGF19
gene regulation
cancer signaling
anticancer
FRS2
FGFR
NVP-BGJ398
LY2874455
sarcoma
cancer-associated fibroblasts
GPER
breast cancer
estrogen
FGFR1
FGF2
optogenetics
ERK
AKT
receptor kinase
neurite outgrowth
HEK293
PC12
fibroblast growth factor receptors
signaling
receptor cross-talk
coreceptor
membrane proteins
FGFR2
ERK1/2
phosphorylation
serine
negative feedback loop
cancer
prognosis
HCC
inhibitors
FGF
fibroblast growth factor
autocrine signaling
skin
melanoma
squamous and basal cell carcinoma
seborrheic keratosis
targeted therapy
resistance
structure
kinase inhibitor
gastric cancer
monoclonal antibody
small molecule
FGFR2c
autophagy
keratinocyte
MTOR
JNK1
review
malignant glioma
brain cancer
astrocytoma
Sprouty proteins
FGF-mediated signaling
tumor suppressor
tumor promoter
malignant pleural mesothelioma
overall survival
immunohistochemistry
infigratinib sensitivity
FGF8
FGF18
adenocarcinoma of the esophagogastric junction
neoadjuvant therapy
n/a
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