Arteriogenesis and Therapeutic Neovascularization

For many years, arteriogenesis, also called collateral formation, has been regarded as being a beneficial process to restore blood flow to distal tissues in occluded arteries. Therefore, it is frequently referred to in relation to therapeutic angiogenesis. Despite the big clinical potential and the...

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Other Authors: Deindl, Elisabeth (Editor), Quax, Paul (Editor), Waltenberger, Johannes (Editor), Schmitz-Rixen, Thomas (Editor)
Format: Book Chapter
Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
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041 0 |a English 
042 |a dc 
072 7 |a M  |2 bicssc 
100 1 |a Deindl, Elisabeth  |4 edt 
700 1 |a Quax, Paul  |4 edt 
700 1 |a Waltenberger, Johannes  |4 edt 
700 1 |a Schmitz-Rixen, Thomas  |4 edt 
700 1 |a Deindl, Elisabeth  |4 oth 
700 1 |a Quax, Paul  |4 oth 
700 1 |a Waltenberger, Johannes  |4 oth 
700 1 |a Schmitz-Rixen, Thomas  |4 oth 
245 1 0 |a Arteriogenesis and Therapeutic Neovascularization 
260 |a Basel, Switzerland  |b MDPI - Multidisciplinary Digital Publishing Institute  |c 2020 
300 |a 1 electronic resource (220 p.) 
506 0 |a Open Access  |2 star  |f Unrestricted online access 
520 |a For many years, arteriogenesis, also called collateral formation, has been regarded as being a beneficial process to restore blood flow to distal tissues in occluded arteries. Therefore, it is frequently referred to in relation to therapeutic angiogenesis. Despite the big clinical potential and the many promising clinical trials on arteriogenesis and therapeutic angiogenesis, the exact molecular mechanisms involved in the multifactorial processes of arteriogenesis are still not completely understood. A better understanding is needed in order to define successful clinical therapies. In this Special Issue, multiple aspects of arteriogenesis and therapeutic angiogenesis will be addressed, ranging from the role of inflammatory processes and immune cells, to growth factors, microRNAs and environmental factors like hypoxia. Therapeutic angiogenesis will also be discussed in relation to the atherosclerosis and intraplaque angiogenesis in hypoxic lesions, as well as specific forms of arteriogenesis in relation to spinal cord blood supply and aorta surgery. The effects of exercise, a frequently prescribed therapy for PAD patients, on arteriogenesis are also discussed. Overall, the papers in this Special Issue on arteriogenesis and therapeutic angiogenesis provide important new insights in the underlying pathophysiological mechanism of these complex processes and may be helpful to define a successful future intervention directed at therapeutic angiogenesis. 
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546 |a English 
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653 |a factor VII activating protease 
653 |a HABP2 
653 |a VEGF 
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653 |a angiogenesis 
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653 |a macrophages 
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653 |a A-to-I editing 
653 |a m6A 
653 |a RNA modifications 
653 |a RNA methylation 
653 |a lower extremity arterial disease 
653 |a peripheral arterial disease 
653 |a blood flow restriction 
653 |a activity-based benefits 
653 |a training effects 
653 |a effect mechanism 
653 |a hyperoxygenation 
653 |a vein graft disease 
653 |a vascular biology 
653 |a spinal cord ischemia 
653 |a paraplegia 
653 |a aortic disease 
653 |a TAAA 
653 |a collateral network 
653 |a paraspinous compartment 
653 |a NO 
653 |a NOTCH 
653 |a innate immunity 
653 |a mast cell 
653 |a GH and eNOS 
653 |a IGF-I 
653 |a oxidative stress and arterial inflammation 
653 |a vascular homeostasis 
653 |a GHAS trial 
653 |a collateral artery growth 
653 |a SMC proliferation 
653 |a potassium channel 
653 |a KV1.3 
653 |a KCa3.1 
653 |a FGFR-1 
653 |a Egr-1 
653 |a PDFG-R 
653 |a αSM-actin 
653 |a TLR2/6 
653 |a femoral artery ligation 
653 |a blood flow recovery 
653 |a collateral growth 
653 |a VHL loss of function 
653 |a microRNA-212/132 
653 |a n/a 
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