Centenarians-A Model to Study the Molecular Basis of Lifespan and Healthspan

People around the world are living longer. For the first time in history, most humans will live to be sixty and beyond. By 2050, the world's population aged 60 and over will reach a total of 2 billion, up from 900 million in 2015. Today, 125 million people are 80 years of age or older. By 2050,...

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Other Authors: Puca, Annibale (Editor), Caruso, Calogero (Editor)
Format: Book Chapter
Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
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Online Access:Get Fullteks
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100 1 |a Puca, Annibale  |4 edt 
700 1 |a Caruso, Calogero  |4 edt 
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245 1 0 |a Centenarians-A Model to Study the Molecular Basis of Lifespan and Healthspan 
260 |a Basel, Switzerland  |b MDPI - Multidisciplinary Digital Publishing Institute  |c 2021 
300 |a 1 electronic resource (204 p.) 
506 0 |a Open Access  |2 star  |f Unrestricted online access 
520 |a People around the world are living longer. For the first time in history, most humans will live to be sixty and beyond. By 2050, the world's population aged 60 and over will reach a total of 2 billion, up from 900 million in 2015. Today, 125 million people are 80 years of age or older. By 2050, there will be 434 million people in this age group worldwide. In addition, the pace of aging of the world population is also increasing. However, there is not enough evidence to show that older people have better health than their parents. While rates of severe disability have declined over the past 30 years (but only in high-income countries), there have been no significant changes in mild to moderate disability over the same period of time. Indeed, the increase in the duration of life (lifespan) does not coincide with the increase in the duration of health (healthspan), that is, the period of life free from serious chronic diseases and disabilities. Therefore, the identification of the factors that predispose to a long and healthy life, as discussed in the papers of this book, is of enormous interest for translational medicine. 
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650 7 |a Research & information: general  |2 bicssc 
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653 |a aging 
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653 |a oxidative stress 
653 |a ageing 
653 |a nematode 
653 |a immunosenescence 
653 |a probiotic bacteria 
653 |a pathogen protection 
653 |a food allergy 
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653 |a inflammation 
653 |a redoxomics 
653 |a glutathione 
653 |a meniere's disease 
653 |a neurodegenerative diseases 
653 |a healthy aging 
653 |a DNA methylation 
653 |a epigenetic clocks 
653 |a telomere length 
653 |a centenarians 
653 |a exosomes 
653 |a serum 
653 |a functional enrichment analysis 
653 |a ingenuity pathway analysis 
653 |a miRNA-mRNA networks 
653 |a aging-related disease 
653 |a Di (2-Ethylhexyl) pthalate 
653 |a Hericium erinaceus 
653 |a vitagenes 
653 |a apoptosis 
653 |a mitochondrial respiratory complexes 
653 |a C. elegans 
653 |a polyphenols 
653 |a olive oil 
653 |a Parkinson's disease 
653 |a β-Dystroglycan 
653 |a cellular senescence 
653 |a lamin B1 
653 |a DNA-damage response 
653 |a defective mitosis 
653 |a n/a 
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