The Shaping of Cancer by the Tumour Microenvironment and Its Relevance for Cancer Therapy

In this book, we present a compilation of original research articles as well as review articles that are focused on improving our understanding of the molecular and cellular mechanisms by which cancer cells adapt to their microenvironment. These include the interplay between cancer cells and the sur...

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Other Authors: Madureira, Patrícia Alexandra Saraiva (Editor)
Format: Book Chapter
Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
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100 1 |a Madureira, Patrícia Alexandra Saraiva  |4 edt 
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245 1 0 |a The Shaping of Cancer by the Tumour Microenvironment and Its Relevance for Cancer Therapy 
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300 |a 1 electronic resource (307 p.) 
506 0 |a Open Access  |2 star  |f Unrestricted online access 
520 |a In this book, we present a compilation of original research articles as well as review articles that are focused on improving our understanding of the molecular and cellular mechanisms by which cancer cells adapt to their microenvironment. These include the interplay between cancer cells and the surrounding microenvironmental cells (e.g., macrophages, tumor-infiltrating lymphocytes and myeloid cells) and microenvironmental environments (e.g., oxidative stress, pH, hypoxia) and the implications of this dynamic interaction to tumor radioresistance, chemoresistance, invasion and metastasis. Finally, the importance and relevance of these findings are translated to cancer therapy. 
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653 |a hypoxia 
653 |a macrophages 
653 |a colon cancer 
653 |a tumor microenvironment 
653 |a immune cell infiltration 
653 |a prognosis 
653 |a feline mammary carcinoma 
653 |a PD-1 
653 |a PD-L1 
653 |a CTLA-4 
653 |a TNF-α 
653 |a biomarkers 
653 |a immunotherapy 
653 |a cancer 
653 |a histone modification 
653 |a inhibitor 
653 |a KDM5B 
653 |a molecular docking 
653 |a repurposing 
653 |a cancer acidity 
653 |a hyperosmolarity 
653 |a cross-presentation 
653 |a tumour microenvironment 
653 |a syngeneic model 
653 |a prostate cancer 
653 |a radiotherapy 
653 |a preclinical modelling 
653 |a myeloid-derived suppressor cells 
653 |a biomarker 
653 |a stroma 
653 |a cancer-associated fibroblast (CAF) 
653 |a extracellular matrix (ECM) 
653 |a cytokine/chemokine 
653 |a growth factors 
653 |a pro- and anti-tumor immune cells 
653 |a immunomodulatory roles 
653 |a radiotherapy dose fractionation 
653 |a radioresistance 
653 |a radiosensitivity 
653 |a breast cancer 
653 |a S100A10 (p11) 
653 |a tumor growth 
653 |a tumor progression 
653 |a metastasis 
653 |a carcinoma 
653 |a mammary gland 
653 |a triple negative 
653 |a pre-metastatic niche 
653 |a pro-inflammatory cytokines 
653 |a clinical trials 
653 |a evolutionary therapy 
653 |a darwinian evolution 
653 |a cancer cells subpopulations 
653 |a diclofenac 
653 |a koningic acid 
653 |a spheroid 
653 |a 3D co-culture 
653 |a microenvironment 
653 |a resistance 
653 |a myeloid cells 
653 |a cancer development 
653 |a molecular subtypes of pancreatic cancer 
653 |a chemotherapy response 
653 |a pancreatic stellate cells 
653 |a regulatory T cells 
653 |a tumor-associated macrophages 
653 |a myeloid derived suppressor cells 
653 |a glioblastoma (GB) 
653 |a Hypoxia Inducible Factor (HIF) 
653 |a glioma stem cells (GSC) 
653 |a oxidative stress 
653 |a reactive oxygen species 
653 |a plasmin 
653 |a plasminogen 
653 |a S100A10 
653 |a uPA 
653 |a uPAR 
653 |a PAI-1 
653 |a PAI-2 
653 |a cancer stem cells 
653 |a cancer recurrence 
653 |a therapeutic resistance 
653 |a signaling pathways 
653 |a targeted therapy 
653 |a head and neck cancer 
653 |a lung cancer 
653 |a bladder cancer 
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