Modern Approaches in Cardiovascular Disease Therapeutics: From Molecular Genetics to Tissue Engineering

Cardiovascular disease (CVD) currently represents one of the leading causes of death worldwide. Each year, more than 17.9 million people die due to CVD manifestations. To reverse these manifestations, the transplantation of secondary vessels or the use of synthetic vascular grafts represents the gol...

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Other Authors: Mallis, Panagiotis (Editor), Michalopoulos, Efstathios (Editor)
Format: Book Chapter
Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
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100 1 |a Mallis, Panagiotis  |4 edt 
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245 1 0 |a Modern Approaches in Cardiovascular Disease Therapeutics: From Molecular Genetics to Tissue Engineering 
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520 |a Cardiovascular disease (CVD) currently represents one of the leading causes of death worldwide. Each year, more than 17.9 million people die due to CVD manifestations. To reverse these manifestations, the transplantation of secondary vessels or the use of synthetic vascular grafts represents the gold standard procedure. However, significant adverse reactions have been described in the literature regarding the use of these type of grafts. In this regard, modern therapeutic strategies focused on CVD therapeutics must be proposed and evaluated. As alternative therapies, advanced tissue engineering approaches, including decellularization procedures and the 3D additive bio-printing methods, are currently being investigated. In this Special Issue of Bioengineering, we aimed to highlight modern approaches regarding CVD. This Special Issue, entitled "Modern Approaches in Cardiovascular Disease Therapeutics: From Molecular Genetics to Tissue Engineering", includes 5 articles. These articles are related to the efficient production of small-diameter vascular grafts, vascular graft development with 3D printing approaches, and in vitro models for the improved assessment of atherosclerosis mechanisms. The Guest Editors of this Special Issue wish to express their gratitude to all contributors for their unique and outstanding articles. Additionally, special credit is given to all reviewers for their comprehensive analysis and overall effort in improving the quality of the published articles. 
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546 |a English 
650 7 |a Medicine  |2 bicssc 
653 |a atherosclerosis 
653 |a monocyte 
653 |a macrophage 
653 |a disease model 
653 |a collagen 
653 |a 3D cell culture 
653 |a immunomechanobiology 
653 |a small-diameter vascular grafts 
653 |a tissue engineering 
653 |a cardiovascular disease 
653 |a vascular reconstruction 
653 |a bypass surgery 
653 |a decellularization 
653 |a human umbilical arteries 
653 |a synthetic materials 
653 |a 3D and 4D printing 
653 |a thermoresponsive materials 
653 |a mesenchymal stromal cells 
653 |a repopulation 
653 |a Ki67 
653 |a MAP kinase 
653 |a 3D bioprinting 
653 |a cell therapy 
653 |a 3D printing 
653 |a macrophages 
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