Coumarin and Its Derivatives
Coumarins are widely distributed in nature and can be found in a large number of naturally occurring and synthetic bioactive molecules. The unique and versatile oxygen-containing heterocyclic structure makes them a privileged scaffold in Medicinal Chemistry. Many coumarin derivatives have been extra...
Saved in:
| Other Authors: | |
|---|---|
| Format: | Book Chapter |
| Published: |
Basel, Switzerland
MDPI - Multidisciplinary Digital Publishing Institute
2021
|
| Subjects: | |
| Online Access: | Get Fullteks DOAB: description of the publication |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| LEADER | 06818naaaa2201813uu 4500 | ||
|---|---|---|---|
| 001 | doab_20_500_12854_77168 | ||
| 005 | 20220111 | ||
| 020 | |a books978-3-0365-2774-1 | ||
| 020 | |a 9783036527758 | ||
| 020 | |a 9783036527741 | ||
| 024 | 7 | |a 10.3390/books978-3-0365-2774-1 |c doi | |
| 041 | 0 | |a English | |
| 042 | |a dc | ||
| 072 | 7 | |a GP |2 bicssc | |
| 072 | 7 | |a PS |2 bicssc | |
| 100 | 1 | |a Matos, Maria João |4 edt | |
| 700 | 1 | |a Matos, Maria João |4 oth | |
| 245 | 1 | 0 | |a Coumarin and Its Derivatives |
| 260 | |a Basel, Switzerland |b MDPI - Multidisciplinary Digital Publishing Institute |c 2021 | ||
| 300 | |a 1 electronic resource (406 p.) | ||
| 506 | 0 | |a Open Access |2 star |f Unrestricted online access | |
| 520 | |a Coumarins are widely distributed in nature and can be found in a large number of naturally occurring and synthetic bioactive molecules. The unique and versatile oxygen-containing heterocyclic structure makes them a privileged scaffold in Medicinal Chemistry. Many coumarin derivatives have been extracted from natural sources, designed, synthetized, and evaluated on different pharmacological targets. In addition, coumarin-based ion receptors, fluorescent probes, and biological stains are growing quickly and have extensive applications to monitor timely enzyme activity, complex biological events, as well as accurate pharmacological and pharmacokinetic properties in living cells. The extraction, synthesis, and biological evaluation of coumarins have become extremely attractive and rapidly developing topics. A large number of research and review papers have compiled information on this important family of compounds in 2020. Research articles, reviews, communications, and concept papers focused on the multidisciplinary profile of coumarins, highlighting natural sources, most recent synthetic pathways, along with the main biological applications and theoretical studies, were the main focus of this book. The huge and growing range of applications of coumarins described in this book is a demonstration of the potential of this family of compounds in Organic Chemistry, Medicinal Chemistry, and different sciences related to the study of natural products. This book includes 23 articles: 17 original papers and six review papers. | ||
| 540 | |a Creative Commons |f https://creativecommons.org/licenses/by/4.0/ |2 cc |4 https://creativecommons.org/licenses/by/4.0/ | ||
| 546 | |a English | ||
| 650 | 7 | |a Research & information: general |2 bicssc | |
| 650 | 7 | |a Biology, life sciences |2 bicssc | |
| 653 | |a coumarin | ||
| 653 | |a hydroxyl-modified coumarin | ||
| 653 | |a photophysical | ||
| 653 | |a thermal and structural characterization | ||
| 653 | |a Glycyrrhiza uralensis | ||
| 653 | |a glycyrol | ||
| 653 | |a liquiritigenin | ||
| 653 | |a cholinesterases | ||
| 653 | |a human monoamine oxidases | ||
| 653 | |a kinetics | ||
| 653 | |a docking simulation | ||
| 653 | |a chalcone | ||
| 653 | |a neurodegenerative diseases | ||
| 653 | |a adenosine receptors | ||
| 653 | |a binding affinity | ||
| 653 | |a docking | ||
| 653 | |a 4-hydroxy-7-methoxycoumarin | ||
| 653 | |a macrophage | ||
| 653 | |a inflammation | ||
| 653 | |a NF-κB | ||
| 653 | |a MAPK | ||
| 653 | |a calanolides | ||
| 653 | |a pseudocalanolides | ||
| 653 | |a calanolide A | ||
| 653 | |a Calophyllum | ||
| 653 | |a Calophyllaceae | ||
| 653 | |a anti-HIV | ||
| 653 | |a reverse transcriptase | ||
| 653 | |a non-nucleoside reverse transcriptase inhibitors (NNRTIs) | ||
| 653 | |a osthole | ||
| 653 | |a umbelliferone | ||
| 653 | |a esculin | ||
| 653 | |a 4-hydroxycoumarin | ||
| 653 | |a sorafenib | ||
| 653 | |a apoptosis | ||
| 653 | |a autophagy | ||
| 653 | |a Yin Chen Hao | ||
| 653 | |a constitutive androstane receptor | ||
| 653 | |a scoparone | ||
| 653 | |a coumarins | ||
| 653 | |a quorum sensing | ||
| 653 | |a QS inhibitors | ||
| 653 | |a plant-derived molecules | ||
| 653 | |a Chromobacterium violaceum | ||
| 653 | |a immunoproteasome | ||
| 653 | |a psoralen core | ||
| 653 | |a non-peptidic | ||
| 653 | |a electrophilic compounds | ||
| 653 | |a warhead scan | ||
| 653 | |a inflammatory bowel disease | ||
| 653 | |a isocoumarin | ||
| 653 | |a Crohn's disease | ||
| 653 | |a ulcerative colitis | ||
| 653 | |a glutathione | ||
| 653 | |a oxidative stress | ||
| 653 | |a complementary therapies | ||
| 653 | |a intestinal inflammation | ||
| 653 | |a benzopyrones | ||
| 653 | |a five-membered aromatic heterocycles | ||
| 653 | |a furan | ||
| 653 | |a pyrrole | ||
| 653 | |a thiophene | ||
| 653 | |a selenophen | ||
| 653 | |a dihydrocoumarin-fused dihydropyranones | ||
| 653 | |a 3-aroylcoumarines | ||
| 653 | |a benzyl 2,3-butadienoate | ||
| 653 | |a 6'-(4-biphenyl)-β-iso-cinchonine | ||
| 653 | |a biological applications | ||
| 653 | |a drug discovery | ||
| 653 | |a fluorescent probes | ||
| 653 | |a warfarin | ||
| 653 | |a acenocoumarol | ||
| 653 | |a mechanical valve | ||
| 653 | |a time in therapeutic range | ||
| 653 | |a anticoagulation | ||
| 653 | |a Ruta chalepensis | ||
| 653 | |a Rutaceae | ||
| 653 | |a chalepin | ||
| 653 | |a chalepensin | ||
| 653 | |a bioactivity | ||
| 653 | |a biosynthesis | ||
| 653 | |a coumarin3-carboxamides | ||
| 653 | |a pyranocoumarins | ||
| 653 | |a anticancer activity | ||
| 653 | |a antibacterial activity | ||
| 653 | |a free radical polymerization | ||
| 653 | |a LED | ||
| 653 | |a photocomposites | ||
| 653 | |a direct laser write | ||
| 653 | |a analytical methods | ||
| 653 | |a model plant | ||
| 653 | |a natural genetic variation | ||
| 653 | |a natural products | ||
| 653 | |a simple coumarins | ||
| 653 | |a chalcocoumarin | ||
| 653 | |a MAO-B | ||
| 653 | |a molecular dynamics | ||
| 653 | |a in silico studies | ||
| 653 | |a dye-sensitized solar cells | ||
| 653 | |a coumarin dyes | ||
| 653 | |a thieno [3,2-b] thiophene | ||
| 653 | |a charge transfer | ||
| 653 | |a ethynylaryl | ||
| 653 | |a esculetin | ||
| 653 | |a antiplatelet activity | ||
| 653 | |a impedance aggregometry | ||
| 653 | |a COX | ||
| 653 | |a polyphenols | ||
| 653 | |a pyrazole | ||
| 653 | |a imidazole | ||
| 653 | |a thiazole | ||
| 653 | |a oxazole | ||
| 653 | |a triazole | ||
| 653 | |a thiadiazole | ||
| 653 | |a curcumin | ||
| 653 | |a curcumin-coumarin hybrids | ||
| 653 | |a neuroprotection | ||
| 653 | |a monoamine oxidase inhibition | ||
| 653 | |a cholinesterase inhibition | ||
| 653 | |a scavenging activity | ||
| 653 | |a Escherichia coli | ||
| 653 | |a biotransformation | ||
| 653 | |a ferulenol | ||
| 653 | |a structural annotation | ||
| 653 | |a in silico tools | ||
| 653 | |a n/a | ||
| 856 | 4 | 0 | |a www.oapen.org |u https://mdpi.com/books/pdfview/book/4786 |7 0 |z Get Fullteks |
| 856 | 4 | 0 | |a www.oapen.org |u https://directory.doabooks.org/handle/20.500.12854/77168 |7 0 |z DOAB: description of the publication |