Monoclonal Antibody-Directed Therapy

Monoclonal Antibody-Directed Therapy

The book deals with therapeutic monoclonal antibodies (mAbs) broadly, and relevant topics such as challenges and opportunities, next-generation antibody products, Antibody-Drug-Conjugates (ADC), bispecifics, glycosylation, and T-cell engagers are covered. Each topic has been written by leading group...

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Další autoři: Kayser, Veysel (Editor), Datta-Mannan, Amita (Editor)
Médium: Kapitola
Vydáno: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
Témata:
Medicine
Pharmaceutical industries
therapeutic antibody
stability
aggregation
manufacture challenges
formulation
antibodies
site-specific conjugation
bioconjugates
ADC
antibody-drug conjugates
payloads
linkers
nucleic acids
ADME
developability
glycosylation
post-translational modifications
pharmacokinetics
effector functions
antibody-dependent cell-mediated cytotoxicity
complement-dependent cytotoxicity
immunogenicity
pharmacodynamics
glycoengineering
type III secretion system
prophylaxis
antibacterials
antibiotics
HIV/AIDS
co-formulation
high concentration
analytical characterization
antibody (s)
T-cell engagers
bispecific antibodies
immunotherapy
oncology
antibody engineering
immunological synapse
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