The Role of Insulin, IGF-1 and PRAS40 in the Processes of Oncogenesis in Women with Type 2 Diabetes Mellitus and Endometrial Cancer
The objective of the research was to investigate the content of insulin, insulin-like growth factor-1 and phosphorylated protein kinase proline-rich Akt substrate of 40kDa and to determine their role in the activation of oncogenesis processes in women with type 2 diabetes mellitus and endometrial ca...
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| Format: | EJournal Article |
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Ivano-Frankivsk National Medical University,
2019-12-28.
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| LEADER | 03293 am a22002773u 4500 | ||
|---|---|---|---|
| 001 | galician_1076_946 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Vatseba, Tamara |e author |
| 245 | 0 | 0 | |a The Role of Insulin, IGF-1 and PRAS40 in the Processes of Oncogenesis in Women with Type 2 Diabetes Mellitus and Endometrial Cancer |
| 260 | |b Ivano-Frankivsk National Medical University, |c 2019-12-28. | ||
| 500 | |a https://ifnmujournal.com/gmj/article/view/1076 | ||
| 520 | |a The objective of the research was to investigate the content of insulin, insulin-like growth factor-1 and phosphorylated protein kinase proline-rich Akt substrate of 40kDa and to determine their role in the activation of oncogenesis processes in women with type 2 diabetes mellitus and endometrial cancer. Materials and methods. There were examined 46 women who were divided into 4 groups: Group I included healthy women; Group II comprised women with type 2 diabetes mellitus; Group III included women with endometrial cancer; Group IV comprised women with endometrial cancer and co-existent type 2 diabetes mellitus. The levels of insulin, insulin-like growth factor-1, phospho- proline-rich Akt substrate of 40kDa were determined by immune-enzyme analysis. The compensation of diabetes mellitus was evaluated by hemoglobin A1c level using method of ion-exchange chromatography. The results obtained were analyzed using statistical analysis. Results. Women of all study groups had increased levels of insulin and insulin-like growth factor-1 as compared to the control group (p<0.05). The level of phospho-proline-rich Akt substrate of 40kDa increased in the patients of Group II (p<0.05) and the patients of Group III (p<0.05) and decreased in the patients of Group IV (p<0.05). According to correlation analysis, phospho-proline-rich Akt substrate of 40kDa was found to correlate with body mass index, insulin and insulin-like growth factor-1 in Group II, body mass index and insulin-like growth factor-1 in Group III and body mass index in Group IV (p<0.05). Conclusions. There was found an association between type 2 diabetes mellitus and endometrial cancer through obesity, hyperinsulinemia and insulin-like growth factor-1. The increase in phospho- proline-rich Akt substrate of 40kDa level was a sign of activation of mTOR and oncogenesis processes in the patients with type 2 diabetes mellitus. The decrease in phospho-proline-rich Akt substrate of 40kDa in the patients with endometrial cancer and co-existent type 2 diabetes mellitus can be explained by the influence of other intracellular regulatory systems or the effects of antidiabetic drugs, that requires additional study. | ||
| 540 | |a Copyright (c) 2019 Tamara Vatseba | ||
| 540 | |a https://creativecommons.org/licenses/by-nc/4.0 | ||
| 546 | |a eng | ||
| 690 | |a diabetes mellitus | ||
| 690 | |a cancer risk | ||
| 690 | |a endometrial cancer | ||
| 690 | |a signaling pathways | ||
| 655 | 7 | |a info:eu-repo/semantics/article |2 local | |
| 655 | 7 | |a info:eu-repo/semantics/publishedVersion |2 local | |
| 786 | 0 | |n Galician Medical Journal; Vol. 26 No. 4 (2019) | |
| 786 | 0 | |n Galician Medical Journal; Том 26 № 4 (2019) | |
| 786 | 0 | |n 2414-1518 | |
| 787 | 0 | |n https://ifnmujournal.com/gmj/article/view/1076/946 | |
| 856 | 4 | 1 | |u https://ifnmujournal.com/gmj/article/view/1076/946 |z Get Fulltext |