Dynamics of Interleukin-4 and Interleukin-8 in Young Children with Complicated Pneumonia Secondary to Iron-Deficiency Anemia
The objective of the research was to study serum levels of pro-inflammatory interleukin-8 and anti-inflammatory interleukin-4 in infants with complicated pneumonia depending on concomitant iron-deficiency as well as to establish their diagnostic value.Materials and methods. The levels of interleukin...
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| Format: | EJournal Article |
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Ivano-Frankivsk National Medical University,
2016-06-30.
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| LEADER | 03659 am a22002653u 4500 | ||
|---|---|---|---|
| 001 | galician_552_524 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Haridzhuk, L. I. |e author |
| 245 | 0 | 0 | |a Dynamics of Interleukin-4 and Interleukin-8 in Young Children with Complicated Pneumonia Secondary to Iron-Deficiency Anemia |
| 260 | |b Ivano-Frankivsk National Medical University, |c 2016-06-30. | ||
| 520 | |a The objective of the research was to study serum levels of pro-inflammatory interleukin-8 and anti-inflammatory interleukin-4 in infants with complicated pneumonia depending on concomitant iron-deficiency as well as to establish their diagnostic value.Materials and methods. The levels of interleukin-4 and interleukin-8 were studied in 80 children with complicated pneumonia at the age of 2 months to 3 years, 60 out of them developed the condition secondary to iron-deficiency anemia. Children were divided into two groups: Group I included patients with complicated pneumonia without iron-deficiency anemia; Group II consisted of patients with complicated pneumonia and concomitant iron-deficiency anemia. In addition, depending on the severity of iron-deficiency anemia Group II was divided into three subgroups: IIa, IIb and IIc - a combination of pneumonia with anemia of mild, moderate and severe degrees, respectively. Serum levels of interleukin-4 and interleukin-8 were determined using enzyme-linked immunosorbent assay by means of standard kit (Vector-Best, Novosibirsk, Russia).Results. Elevated levels of pro-inflammatory interleukin-8 and anti-inflammatory interleukin-4 were typical for all young children with acute complicated pneumonia (р<0.01). At the same time, in patients with complicated pneumonia secondary to iron-deficiency anemia these parameters were significantly higher compared to those in children with complicated pneumonia without iron-deficiency anemia (р<0.001). In the convalescence period a significant reduction in the levels of interleukin-8 was observed in all groups of children, while the concentration of interleukin-4 increased significantly (р<0.001).Conclusions. Elevated levels of pro-inflammatory interleukin-8 and anti-inflammatory interleukin-4 were typical for all young children in the acute phase of complicated pneumonia. At the same time, in patients with complicated pneumonia secondary to iron-deficiency anemia these parameters were significantly higher compared to those in children with complicated pneumonia without iron-deficiency anemia (р<0.001). In the convalescence period a significant reduction in the levels of interleukin-8 was observed in all groups of children (p<0.01); however, it did not reach the indicators of age norm (p<0.001), while the concentration of interleukin-4 increased significantly (p<0.001). In patients with complicated pneumonia secondary to severe iron-deficiency anemia changes in the concentrations of interleukin-8 and interleukin-4 were more significant compared to patients with complicated pneumonia without iron-deficiency anemia. | ||
| 540 | |a Copyright (c) 2017 L. I. Haridzhuk | ||
| 540 | |a https://creativecommons.org/licenses/by-nc/4.0 | ||
| 546 | |a eng | ||
| 690 | |a children | ||
| 690 | |a pneumonia | ||
| 690 | |a anemia | ||
| 690 | |a interleukins | ||
| 655 | 7 | |a info:eu-repo/semantics/article |2 local | |
| 655 | 7 | |a info:eu-repo/semantics/publishedVersion |2 local | |
| 786 | 0 | |n Galician Medical Journal; Vol. 23 No. 2 (2016); 133-138 | |
| 786 | 0 | |n Galician Medical Journal; Том 23 № 2 (2016); 133-138 | |
| 786 | 0 | |n 2414-1518 | |
| 787 | 0 | |n https://ifnmujournal.com/gmj/article/view/552/524 | |
| 856 | 4 | 1 | |u https://ifnmujournal.com/gmj/article/view/552/524 |z Get Fulltext |