Ultrastructural Changes in the Vessels of Hemomicrocirculatory Bed of the Iliac Lymph Nodes of White Rats in the Durable Action of the Opioid Nalbuphine
This article represents the electronic-microscopic examination of blood vessels of the hemomicrocirculatory bed of the iliac lymph nodes of white rats, males of reproductive age, who, during six weeks, received narcotic opioid analgesic - nalbuphine, increasing the weekly dose of the medicine to cre...
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| Format: | EJournal Article |
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Ivano-Frankivsk National Medical University,
2018-04-02.
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| Online Access: | Get Fulltext |
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| LEADER | 02439 am a22003253u 4500 | ||
|---|---|---|---|
| 001 | galician_868_794 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Valko, Olesya |e author |
| 700 | 1 | 0 | |a Holovatsky, Andriy |e author |
| 245 | 0 | 0 | |a Ultrastructural Changes in the Vessels of Hemomicrocirculatory Bed of the Iliac Lymph Nodes of White Rats in the Durable Action of the Opioid Nalbuphine |
| 260 | |b Ivano-Frankivsk National Medical University, |c 2018-04-02. | ||
| 500 | |a https://ifnmujournal.com/gmj/article/view/868 | ||
| 520 | |a This article represents the electronic-microscopic examination of blood vessels of the hemomicrocirculatory bed of the iliac lymph nodes of white rats, males of reproductive age, who, during six weeks, received narcotic opioid analgesic - nalbuphine, increasing the weekly dose of the medicine to create a model of physical opioid dependence according to Ukraine Patent #76564 U.It was determined that opioid nalbuphine causes the reactive changes in the blood vessels of the hemomicrocirculatory bed of the iliac lymph nodes in the early stages of drug administration - within 1-2 weeks. A prolonged six-week administration of nalbuphine leads to profound destructive changes in the microvessels: the lumen of the hemocapillaries, which contains mainly the destructively altered erythrocytes, is expanding; the wall of microvessels, accompanied by hemorrhages into the vascular space, is violated; the structure of endotheliocytes nuclei changes, their cytoplasm swells, and organelles are damaged in it; the basement membrane thickens; the perivascular space swells and dilates. One week after the abolition of nalbuphine, the inverse changes in the blood vessels of hemomicrocirculatory bed do not occur. | ||
| 540 | |a Copyright (c) 2018 Olesya Valko, Andriy Holovatsky | ||
| 540 | |a https://creativecommons.org/licenses/by-nc/4.0 | ||
| 546 | |a eng | ||
| 690 | |a lymph node | ||
| 690 | |a hemocapillary | ||
| 690 | |a venule | ||
| 690 | |a endotheliocyte | ||
| 690 | |a nalbuphine | ||
| 690 | |a effect | ||
| 690 | |a white rat | ||
| 655 | 7 | |a info:eu-repo/semantics/article |2 local | |
| 655 | 7 | |a info:eu-repo/semantics/publishedVersion |2 local | |
| 786 | 0 | |n Galician Medical Journal; Vol. 25 No. 1 (2018) | |
| 786 | 0 | |n Galician Medical Journal; Том 25 № 1 (2018) | |
| 786 | 0 | |n 2414-1518 | |
| 787 | 0 | |n https://ifnmujournal.com/gmj/article/view/868/794 | |
| 856 | 4 | 1 | |u https://ifnmujournal.com/gmj/article/view/868/794 |z Get Fulltext |