p300/CBP Methylation is Involved in the Potential Carcinogenic Mechanism of Lung Cancer
p300/CBP is involved in the expression of a wide range of genes, both as a histone acetyltransferase (HAT) and as a coactivator of transcription factors. p300/CBP is the specific substrate of CARM1, and its KIX domain and GBD domain are the main sites methylated by arginine methyltransferase 4 (PRMT...
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IntechOpen,
2021-04-13.
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| LEADER | 01719 am a22002293u 4500 | ||
|---|---|---|---|
| 001 | intechopen_books_10240 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Zhang, Yu |e author |
| 700 | 1 | 0 | |a Shen, Wei |e author |
| 700 | 1 | 0 | |a Zou, Jin |e author |
| 700 | 1 | 0 | |a Ying, Shibo |e author |
| 245 | 0 | 0 | |a p300/CBP Methylation is Involved in the Potential Carcinogenic Mechanism of Lung Cancer |
| 260 | |b IntechOpen, |c 2021-04-13. | ||
| 500 | |a https://mts.intechopen.com/articles/show/title/p300-cbp-methylation-is-involved-in-the-potential-carcinogenic-mechanism-of-lung-cancer | ||
| 520 | |a p300/CBP is involved in the expression of a wide range of genes, both as a histone acetyltransferase (HAT) and as a coactivator of transcription factors. p300/CBP is the specific substrate of CARM1, and its KIX domain and GBD domain are the main sites methylated by arginine methyltransferase 4 (PRMT4/CARM1). p300/CBP plays an important role in lung cancer, which is a cell cycle disease. More importantly, the methylation of p300/CBP by CARM1 affects the progression of lung cancer through the cAMP-PKA pathway, p53 pathway and ER pathway. The structure, function, methylation modification sites, methylation-related enzymes, genes associated with lung cancer and the possible mechanisms of p300/CBP action are reviewed. | ||
| 540 | |a https://creativecommons.org/licenses/by/3.0/ | ||
| 546 | |a en | ||
| 690 | |a Post-Translational Modifications in Cellular Functions and Diseases | ||
| 655 | 7 | |a Chapter, Part Of Book |2 local | |
| 786 | 0 | |n https://www.intechopen.com/books/10240 | |
| 787 | 0 | |n ISBN:978-1-83969-047-1 | |
| 856 | \ | \ | |u https://mts.intechopen.com/articles/show/title/p300-cbp-methylation-is-involved-in-the-potential-carcinogenic-mechanism-of-lung-cancer |z Get Online |