Lipoprotein-Associated Phospholipase A2 - Pathophysiological Role and Clinical Significance as a Cardiovascular Biomarker
Within the last decade, a broad range of biomarkers associated with an increased risk for death and cardiovascular/cerebrovascular endpoints have been identified. Epidemiological studies clearly indicate that lipoprotein-associated phospholipase A2 (Lp-PLA2) has the potential to become clinically us...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Ebooks |
| Published: |
IntechOpen,
2015-10-07.
|
| Subjects: | |
| Online Access: | Get Online |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Within the last decade, a broad range of biomarkers associated with an increased risk for death and cardiovascular/cerebrovascular endpoints have been identified. Epidemiological studies clearly indicate that lipoprotein-associated phospholipase A2 (Lp-PLA2) has the potential to become clinically useful emerging biomarker in the true sense, linking plaque biology with cardiovascular/cerebrovascular event rate. Lipoprotein-associated phospholipase A2 is a specific vascular inflammatory marker, a risk factor, a prognostic biomarker, and also a therapeutic target. This chapter will summarize our current knowledge on Lp-PLA2 with emphasis on its potential pathophysiological mechanisms of action and on clinical relevance as cardiovascular/cerebrovascular biomarker. This chapter gives comprehensive, systematic review of studies assessing the significance of Lp-PLA2 in cardiovascular/cerebrovascular diseases with emphasis on clinical benefit of pharmacologic inhibition of Lp-PLA2. |
|---|---|
| Item Description: | https://mts.intechopen.com/articles/show/title/lipoprotein-associated-phospholipase-a2-pathophysiological-role-and-clinical-significance-as-a-cardi |