Vitamin K2 and its Impact on Tooth Epigenetics

The impact of nutritional signals plays an important role in systemic-based «models» of dental caries. Present hypotheses now focus both on the oral environment and other organs, like the nervous system and brain. The tooth is subjected to shear forces, nourishing and cleansing, and its present &quo...

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Главные авторы: Gordeladze, Jan Oxholm (Автор), Landin, Maria A. (Автор), Johnsen, Gaute Floer (Автор), Haugen, Håvard Jostein (Автор), Osmundsen, Harald (Автор)
Формат: Ebooks
Опубликовано: IntechOpen, 2017-03-22.
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100 1 0 |a Gordeladze, Jan Oxholm  |e author 
700 1 0 |a Landin, Maria A.  |e author 
700 1 0 |a Johnsen, Gaute Floer  |e author 
700 1 0 |a Haugen, Håvard Jostein  |e author 
700 1 0 |a Osmundsen, Harald  |e author 
245 0 0 |a Vitamin K2 and its Impact on Tooth Epigenetics 
260 |b IntechOpen,   |c 2017-03-22. 
500 |a https://mts.intechopen.com/articles/show/title/vitamin-k2-and-its-impact-on-tooth-epigenetics 
520 |a The impact of nutritional signals plays an important role in systemic-based «models» of dental caries. Present hypotheses now focus both on the oral environment and other organs, like the nervous system and brain. The tooth is subjected to shear forces, nourishing and cleansing, and its present "support system" (the hypothalamus/parotid axis) relays endocrine signaling to the parotid gland. Sugar consumption enhances hypothalamic oxidative stress (ROS), reversing dentinal fluid flow, thus creating an enhanced vulnerability to the oral bacterial flora. The acid, produced by the oral bacterial flora, then leads to erosion of the dentine, and an irreversible loss of dental enamel layers. This attack brings about inflammatory responses, yielding metalloproteinase-based "dissolution". However, vitamin K2 (i.e. MK-4/MK-7) may come to the rescue with its antioxidant property, locally (mouth cavity) or systemically (via the brain), thus sustaining/preserving hormone-induced dentinal fluid flow (encompassing oxidative stress) and boosting/magnifying bodily inflammatory responses. However, sugars may also reduce the tooth's natural defences through endocrine signaling, thus enhancing acid-supported enamel dentine erosion. Vitamin K2 sustains and improves the salivary buffering capacity via its impact on the secretion/flow of calcium and inorganic phosphates. Interestingly, primitive cultures' diets (low-sugar and high-K2 diets) preserve dental health. 
540 |a https://creativecommons.org/licenses/by/3.0/ 
546 |a en 
690 |a Vitamin K2 - Vital for Health and Wellbeing 
655 7 |a Chapter, Part Of Book  |2 local 
786 0 |n https://www.intechopen.com/books/5169 
787 0 |n ISBN:978-953-51-3019-2 
856 \ \ |u https://mts.intechopen.com/articles/show/title/vitamin-k2-and-its-impact-on-tooth-epigenetics  |z Get Online