Phenolics from Glycyrrhiza glabra and G. uralensis Roots and Their PPAR-γ Ligand-Binding Activity: Possible Application for Amelioration of Type 2 Diabetes
The EtOH extract of Glycyrrhiza glabra roots and the EtOAc extract of Glycyrrhiza uralensis roots exhibited considerable PPAR-γ ligand-binding activity. Bioassay-guided fractionation of these extracts resulted in the isolation of 52 phenolics, including 11 novel ones. The PPAR-γ ligand-binding activ...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Ebooks |
| Published: |
IntechOpen,
2017-05-03.
|
| Subjects: | |
| Online Access: | Get Online |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| LEADER | 01665 am a22002053u 4500 | ||
|---|---|---|---|
| 001 | intechopen_books_5680 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Kuroda, Minpei |e author |
| 700 | 1 | 0 | |a Mimaki, Yoshihiro |e author |
| 245 | 0 | 0 | |a Phenolics from Glycyrrhiza glabra and G. uralensis Roots and Their PPAR-γ Ligand-Binding Activity: Possible Application for Amelioration of Type 2 Diabetes |
| 260 | |b IntechOpen, |c 2017-05-03. | ||
| 500 | |a https://mts.intechopen.com/articles/show/title/phenolics-from-glycyrrhiza-glabra-and-g-uralensis-roots-and-their-ppar-ligand-binding-activity-possi | ||
| 520 | |a The EtOH extract of Glycyrrhiza glabra roots and the EtOAc extract of Glycyrrhiza uralensis roots exhibited considerable PPAR-γ ligand-binding activity. Bioassay-guided fractionation of these extracts resulted in the isolation of 52 phenolics, including 11 novel ones. The PPAR-γ ligand-binding activity of more than 10 isolated phenolics at 10 μg/mL was approximately three times greater than that of 0.5 μM triglitazone. Glycyrin (44), isolated from the EtOAc extract of G. uralensis roots as a PPAR-γ ligand, reduced the blood glucose levels of genetically diabetic KK-Ay mice through its PPAR-γ ligand-binding activity. | ||
| 540 | |a https://creativecommons.org/licenses/by/3.0/ | ||
| 546 | |a en | ||
| 690 | |a Biological Activities and Action Mechanisms of Licorice Ingredients | ||
| 655 | 7 | |a Chapter, Part Of Book |2 local | |
| 786 | 0 | |n https://www.intechopen.com/books/5680 | |
| 787 | 0 | |n ISBN:978-953-51-3119-9 | |
| 856 | \ | \ | |u https://mts.intechopen.com/articles/show/title/phenolics-from-glycyrrhiza-glabra-and-g-uralensis-roots-and-their-ppar-ligand-binding-activity-possi |z Get Online |