The Genotyping of Glucose 6 Phosphate Dehydrogenase deficiency (G6PD-d) in Malaria Endemic South Central Timor, East Nusa Tenggara, Eastern Indonesia
Approximately 18 million people live in malaria-endemic areas with 218,450 reported confirmed cases and 161 reported deaths in Indonesia. Currently, primaquine (PQ), the 8-aminoquinolines, is still the only drug for radical cure and preventing relapse of malaria. However, the individuals with G6PD d...
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2019-11-27.
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| LEADER | 02350 am a22002293u 4500 | ||
|---|---|---|---|
| 001 | intechopen_books_6893 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Hutagalung, Jontari |e author |
| 700 | 1 | 0 | |a Soleha, M. |e author |
| 700 | 1 | 0 | |a Sitorus, Nikson |e author |
| 700 | 1 | 0 | |a Hananta, Linawati |e author |
| 245 | 0 | 0 | |a The Genotyping of Glucose 6 Phosphate Dehydrogenase deficiency (G6PD-d) in Malaria Endemic South Central Timor, East Nusa Tenggara, Eastern Indonesia |
| 260 | |b IntechOpen, |c 2019-11-27. | ||
| 500 | |a https://mts.intechopen.com/articles/show/title/the-genotyping-of-glucose-6-phosphate-dehydrogenase-deficiency-g6pd-d-in-malaria-endemic-south-centr | ||
| 520 | |a Approximately 18 million people live in malaria-endemic areas with 218,450 reported confirmed cases and 161 reported deaths in Indonesia. Currently, primaquine (PQ), the 8-aminoquinolines, is still the only drug for radical cure and preventing relapse of malaria. However, the individuals with G6PD deficiency (G6PD-d) have risk of hemolysis. Currently, few data of the prevalence of G6PD-d and genotyping are available. This study will provide the prevalence of G6PD-d and the genotyping in malaria cases in South Central Timor (TTS) district. G6PD status was analyzed with quantitative (Randox G6PD test, UK) follow with PCR-RFLP and sequencing to identify the variant of G6PD-d genotyping. Malaria was confirmed by n-PCR (Promega, Madison, USA). A total 64 of 181 individuals with G6PD-d from South Central Timor (TTS) district were analyzed. About 25 of 64 cases of G6PD-d were tested positive for malaria with P. vivax as the dominant species 56% (14/25) and most of the cases were female 73.3% (11/15). Among the 64 G6PD-d the genotyping Vanua Lava (10,883 T>C) WHO classifies G6PD-d genetic variants class II with severe deficiency <10% the enzyme activity were dominant. The variant of Vanua Lava is dominant and the high G6PD-d indicated that screening for G6PD deficiency is necessary. | ||
| 540 | |a https://creativecommons.org/licenses/by/3.0/ | ||
| 546 | |a en | ||
| 690 | |a Endemic Species | ||
| 655 | 7 | |a Chapter, Part Of Book |2 local | |
| 786 | 0 | |n https://www.intechopen.com/books/6893 | |
| 787 | 0 | |n ISBN:978-1-83968-252-0 | |
| 856 | \ | \ | |u https://mts.intechopen.com/articles/show/title/the-genotyping-of-glucose-6-phosphate-dehydrogenase-deficiency-g6pd-d-in-malaria-endemic-south-centr |z Get Online |