The BDNF Loop 4 Dipeptide Mimetic Bis(<em>N</em>-monosuccinyl-L-seryl-L-lysine)hexamethylenediamide Is Active in a Depression Model in Mice after Acute Oral Administration
Low-molecular mimetic BDNF GSB-106, which is a substituted dimeric dipeptide, bis(N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide, was designed and synthesized in the V. V. Zakusov Research Institute of Pharmacology. The dipeptide activates TrkB, PI3K/AKT, and MAPK/ ERK. GSB-106 is being devel...
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2019-10-23.
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| LEADER | 02034 am a22002773u 4500 | ||
|---|---|---|---|
| 001 | intechopen_books_7116 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Povarnina, Polina |e author |
| 700 | 1 | 0 | |a Firsova, Yulia N. |e author |
| 700 | 1 | 0 | |a Tallerova, Anna V. |e author |
| 700 | 1 | 0 | |a Mezhlumyan, Аrmen G. |e author |
| 700 | 1 | 0 | |a Kruglov, Sergey V. |e author |
| 700 | 1 | 0 | |a Antipova, Tatiana A. |e author |
| 700 | 1 | 0 | |a Gudasheva, Tatiana A. |e author |
| 700 | 1 | 0 | |a Seredenin, Sergey B. |e author |
| 245 | 0 | 0 | |a The BDNF Loop 4 Dipeptide Mimetic Bis(<em>N</em>-monosuccinyl-L-seryl-L-lysine)hexamethylenediamide Is Active in a Depression Model in Mice after Acute Oral Administration |
| 260 | |b IntechOpen, |c 2019-10-23. | ||
| 500 | |a https://mts.intechopen.com/articles/show/title/the-bdnf-loop-4-dipeptide-mimetic-bis-em-n-em-monosuccinyl-l-seryl-l-lysine-hexamethylenediamide-is- | ||
| 520 | |a Low-molecular mimetic BDNF GSB-106, which is a substituted dimeric dipeptide, bis(N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide, was designed and synthesized in the V. V. Zakusov Research Institute of Pharmacology. The dipeptide activates TrkB, PI3K/AKT, and MAPK/ ERK. GSB-106 is being developed as a potential antidepressant. Its antidepressant activity was detected in a number of rodent tests (0.1-1.0 mg/kg, ip; 0.5-5.0 mg/kg, po). In the present study, GSB-106 was shown to completely eliminate the manifestation of anhedonia in the sucrose preference test and to increase disturbed hippocampal synaptogenesis at acute oral administration (0.1 mg/kg) after 10-day social defeat stress in C57Bl/6 mice. | ||
| 540 | |a https://creativecommons.org/licenses/by/3.0/ | ||
| 546 | |a en | ||
| 690 | |a Antidepressants - Preclinical, Clinical and Translational Aspects | ||
| 655 | 7 | |a Chapter, Part Of Book |2 local | |
| 786 | 0 | |n https://www.intechopen.com/books/7116 | |
| 787 | 0 | |n ISBN:978-1-78985-266-0 | |
| 856 | \ | \ | |u https://mts.intechopen.com/articles/show/title/the-bdnf-loop-4-dipeptide-mimetic-bis-em-n-em-monosuccinyl-l-seryl-l-lysine-hexamethylenediamide-is- |z Get Online |