The BDNF Loop 4 Dipeptide Mimetic Bis(<em>N</em>-monosuccinyl-L-seryl-L-lysine)hexamethylenediamide Is Active in a Depression Model in Mice after Acute Oral Administration

The BDNF Loop 4 Dipeptide Mimetic Bis(<em>N</em>-monosuccinyl-L-seryl-L-lysine)hexamethylenediamide Is Active in a Depression Model in Mice after Acute Oral Administration

Low-molecular mimetic BDNF GSB-106, which is a substituted dimeric dipeptide, bis(N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide, was designed and synthesized in the V. V. Zakusov Research Institute of Pharmacology. The dipeptide activates TrkB, PI3K/AKT, and MAPK/ ERK. GSB-106 is being devel...

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Main Authors: Povarnina, Polina (Author), Firsova, Yulia N. (Author), Tallerova, Anna V. (Author), Mezhlumyan, Аrmen G. (Author), Kruglov, Sergey V. (Author), Antipova, Tatiana A. (Author), Gudasheva, Tatiana A. (Author), Seredenin, Sergey B. (Author)
Format: Ebooks
Published: IntechOpen, 2019-10-23.
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