Cerebral Vascular Tone Regulation: Integration and Impact of Disease
This chapter summarizes the current knowledge regarding the regulation of the tone of cerebral resistance arteries under conditions of normal health and with the development of chronic diseases (e.g., metabolic disease). The work integrates the myogenic (pressure-induced) regulation of vascular tone...
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| Main Authors: | , |
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| Format: | Ebooks |
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IntechOpen,
2020-05-29.
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| Online Access: | Get Online |
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| Summary: | This chapter summarizes the current knowledge regarding the regulation of the tone of cerebral resistance arteries under conditions of normal health and with the development of chronic diseases (e.g., metabolic disease). The work integrates the myogenic (pressure-induced) regulation of vascular tone, the impact of elevated luminal flow or shear stresses, that of local tissue metabolic activity on vascular tone and the concept of neurovascular coupling (linking neuronal activity to the impacts on vascular diameter). In addition, this work summarizes some of the recent work on how diseases such as type 2 diabetes impact the mechanisms of cerebrovascular tone regulation. It is anticipated that the current review will provide the reader with an up-to-date understanding of how the cerebral resistance vessels respond to changes in their local environment and contribute to the regulation of blood flow within the brain. |
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| Item Description: | https://mts.intechopen.com/articles/show/title/cerebral-vascular-tone-regulation-integration-and-impact-of-disease |