Structural Insight into Regulation of the Proteasome Ub-Receptor Rpn10
Ubiquitylation is a posttranslational modification that determines protein fate. The ubiquitin code is written by enzymatic cascades of E1 and E2 and E3 enzymes. Ubiquitylation can be edited or erased by deubiquitylating enzymes. Ub-receptors are proteins that read and decipher the ubiquitin codes i...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Ebooks |
| Published: |
IntechOpen,
2019-06-19.
|
| Subjects: | |
| Online Access: | Get Online |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| LEADER | 01831 am a22002533u 4500 | ||
|---|---|---|---|
| 001 | intechopen_books_8301 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Keren-Kaplan, Tal |e author |
| 700 | 1 | 0 | |a Attali, Ilan |e author |
| 700 | 1 | 0 | |a Levin-Kravets, Olga |e author |
| 700 | 1 | 0 | |a Kleifeld, Oded |e author |
| 700 | 1 | 0 | |a Ben-Aroya, Shay |e author |
| 700 | 1 | 0 | |a Prag, Gali |e author |
| 245 | 0 | 0 | |a Structural Insight into Regulation of the Proteasome Ub-Receptor Rpn10 |
| 260 | |b IntechOpen, |c 2019-06-19. | ||
| 500 | |a https://mts.intechopen.com/articles/show/title/structural-insight-into-regulation-of-the-proteasome-ub-receptor-rpn10 | ||
| 520 | |a Ubiquitylation is a posttranslational modification that determines protein fate. The ubiquitin code is written by enzymatic cascades of E1 and E2 and E3 enzymes. Ubiquitylation can be edited or erased by deubiquitylating enzymes. Ub-receptors are proteins that read and decipher the ubiquitin codes into cellular response. They harbor a ubiquitin-binding domain and a response element. Interestingly, Ub-receptors are also regulated by ubiquitylation and deubiquitylation. However, until recently, the molecular details and the significance of this regulation remained enigmatic. Rpn10 is a Ub-receptor that shuttles ubiquitylated targets to the proteasome for degradation. Here we review recent data on Rpn10, with emphasis on its regulation by ubiquitylation. | ||
| 540 | |a https://creativecommons.org/licenses/by/3.0/ | ||
| 546 | |a en | ||
| 690 | |a Ubiquitin Proteasome System - Current Insights into Mechanism Cellular Regulation and Disease | ||
| 655 | 7 | |a Chapter, Part Of Book |2 local | |
| 786 | 0 | |n https://www.intechopen.com/books/8301 | |
| 787 | 0 | |n ISBN:978-1-83880-490-9 | |
| 856 | \ | \ | |u https://mts.intechopen.com/articles/show/title/structural-insight-into-regulation-of-the-proteasome-ub-receptor-rpn10 |z Get Online |