Levodopa-Induced Dyskinesias and Dyskinesias-Reduced-Self-Awareness in Parkinson's Disease: A Neurocognitive Approach
Levodopa-induced dyskinesias are one of the most common disabling motor complications in advanced Parkinson's disease. The subjective perception of motor impairment is a clinical phenomenon that needs to be adequately analyzed. Indeed, the determination of patient dyskinesias-reduced-self-aware...
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IntechOpen,
2019-05-16.
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| LEADER | 02268 am a22002413u 4500 | ||
|---|---|---|---|
| 001 | intechopen_books_8626 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Palermo, Sara |e author |
| 700 | 1 | 0 | |a Morese, Rosalba |e author |
| 700 | 1 | 0 | |a Artusi, Carlo Alberto |e author |
| 700 | 1 | 0 | |a Stanziano, Mario |e author |
| 700 | 1 | 0 | |a Romagnolo, Alberto |e author |
| 245 | 0 | 0 | |a Levodopa-Induced Dyskinesias and Dyskinesias-Reduced-Self-Awareness in Parkinson's Disease: A Neurocognitive Approach |
| 260 | |b IntechOpen, |c 2019-05-16. | ||
| 500 | |a https://mts.intechopen.com/articles/show/title/levodopa-induced-dyskinesias-and-dyskinesias-reduced-self-awareness-in-parkinson-s-disease-a-neuroco | ||
| 520 | |a Levodopa-induced dyskinesias are one of the most common disabling motor complications in advanced Parkinson's disease. The subjective perception of motor impairment is a clinical phenomenon that needs to be adequately analyzed. Indeed, the determination of patient dyskinesias-reduced-self-awareness (DRSA) and of its relationship to daily dysfunction is an important aspect of the debate on the gold standard for treatment. As the association with executive dysfunction is a matter of debate and we hypothesize it plays an important role in DRSA, we analyzed metacognitive abilities related to action monitoring and other factors, such as response-inhibition and "Theory of Mind," which represent a novel explanation of the phenomenon. Moreover, we investigated whether and how a dysfunction in action monitoring related to the cingulo-frontal-ventral striatal circuit would be associated with DRSA using an event-related Go-NoGo fMRI experiment. Our findings suggest the presence of executive dysfunctions in DRSA pathogenesis, with a key leading role played by the cingulo-frontal network as part of a functionally impaired response-inhibition network. | ||
| 540 | |a https://creativecommons.org/licenses/by/3.0/ | ||
| 546 | |a en | ||
| 690 | |a Parkinson's Disease and Beyond - A Neurocognitive Approach | ||
| 655 | 7 | |a Chapter, Part Of Book |2 local | |
| 786 | 0 | |n https://www.intechopen.com/books/8626 | |
| 787 | 0 | |n ISBN:978-1-83962-648-7 | |
| 856 | \ | \ | |u https://mts.intechopen.com/articles/show/title/levodopa-induced-dyskinesias-and-dyskinesias-reduced-self-awareness-in-parkinson-s-disease-a-neuroco |z Get Online |