Catalytic Intermolecular Functionalization of Benzimidazoles
This chapter describes contemporary strategies for selective catalytic intermolecular functionalization of the benzimidazole scaffold. Functionalization at nitrogen and position C-2 is well developed employing copper, palladium, rhodium, nickel, and cobalt catalysis. Direct CH activation is the pred...
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IntechOpen,
2019-06-25.
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| LEADER | 01681 am a22002053u 4500 | ||
|---|---|---|---|
| 001 | intechopen_books_8852 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Hansen, Jørn H. |e author |
| 700 | 1 | 0 | |a Fjellaksel, Richard |e author |
| 245 | 0 | 0 | |a Catalytic Intermolecular Functionalization of Benzimidazoles |
| 260 | |b IntechOpen, |c 2019-06-25. | ||
| 500 | |a https://mts.intechopen.com/articles/show/title/catalytic-intermolecular-functionalization-of-benzimidazoles | ||
| 520 | |a This chapter describes contemporary strategies for selective catalytic intermolecular functionalization of the benzimidazole scaffold. Functionalization at nitrogen and position C-2 is well developed employing copper, palladium, rhodium, nickel, and cobalt catalysis. Direct CH activation is the predominant approach to C-2 functionalization. Nickel-based catalysts can activate C-O bonds in conjunction with C-H activation at benzimidazole which grants access to a very broad range of phenols and enols as convenient functionalization precursors in this chemistry. The remaining carbon positions of benzimidazoles are typically functionalized via a sequential halogenation/coupling strategy to ensure selectivity. A key success factor in enabling these chemistries has been the fine-tuning of catalyst-ligand combinations. | ||
| 540 | |a https://creativecommons.org/licenses/by/3.0/ | ||
| 546 | |a en | ||
| 690 | |a Chemistry and Applications of Benzimidazole and its Derivatives | ||
| 655 | 7 | |a Chapter, Part Of Book |2 local | |
| 786 | 0 | |n https://www.intechopen.com/books/8852 | |
| 787 | 0 | |n ISBN:978-1-78984-552-5 | |
| 856 | \ | \ | |u https://mts.intechopen.com/articles/show/title/catalytic-intermolecular-functionalization-of-benzimidazoles |z Get Online |