Scaffolding Contigs Using Multiple Reference Genomes
Scaffolding is an important step of the genome assembly and its function is to order and orient the contigs in the assembly of a draft genome into larger scaffolds. Several single reference-based scaffolders have currently been proposed. However, a single reference genome may not be sufficient alone...
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2020-08-21.
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| LEADER | 01793 am a22002173u 4500 | ||
|---|---|---|---|
| 001 | intechopen_books_9346 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Shieh, Yi-Kung |e author |
| 700 | 1 | 0 | |a Liu, Shu-Cheng |e author |
| 700 | 1 | 0 | |a Lu, Chin Lung |e author |
| 245 | 0 | 0 | |a Scaffolding Contigs Using Multiple Reference Genomes |
| 260 | |b IntechOpen, |c 2020-08-21. | ||
| 500 | |a https://mts.intechopen.com/articles/show/title/scaffolding-contigs-using-multiple-reference-genomes | ||
| 520 | |a Scaffolding is an important step of the genome assembly and its function is to order and orient the contigs in the assembly of a draft genome into larger scaffolds. Several single reference-based scaffolders have currently been proposed. However, a single reference genome may not be sufficient alone for a scaffolder to correctly scaffold a target draft genome, especially when the target genome and the reference genome have distant evolutionary relationship or some rearrangements. This motivates researchers to develop the so-called multiple reference-based scaffolders that can utilize multiple reference genomes, which may provide different but complementary types of scaffolding information, to scaffold the target draft genome. In this chapter, we will review some of the state-of-the-art multiple reference-based scaffolders, such as Ragout, MeDuSa and Multi-CAR, and give a complete introduction to Multi-CSAR, an improved extension of Multi-CAR. | ||
| 540 | |a https://creativecommons.org/licenses/by/3.0/ | ||
| 546 | |a en | ||
| 690 | |a Computational Biology and Chemistry | ||
| 655 | 7 | |a Chapter, Part Of Book |2 local | |
| 786 | 0 | |n https://www.intechopen.com/books/9346 | |
| 787 | 0 | |n ISBN:978-1-78985-366-7 | |
| 856 | \ | \ | |u https://mts.intechopen.com/articles/show/title/scaffolding-contigs-using-multiple-reference-genomes |z Get Online |