Calcium Signaling in Human Health and Diseases
Intracellular Ca2+ signals regulate a myriad of cellular functions, ranging from short-term responses, such as excitation-contraction coupling and stimulus-secretion coupling, to long-term processes, such as proliferation, gene expression, differentiation, motility, synaptic plasticity, programmed c...
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| Format: | Ebooks |
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MDPI - Multidisciplinary Digital Publishing Institute,
2019.
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| Online Access: | Get Fulltext |
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| Summary: | Intracellular Ca2+ signals regulate a myriad of cellular functions, ranging from short-term responses, such as excitation-contraction coupling and stimulus-secretion coupling, to long-term processes, such as proliferation, gene expression, differentiation, motility, synaptic plasticity, programmed cell death (or apoptosis), and metabolism. It is, therefore, not surprising that any derangement of the multifaceted Ca2+ toolkit that shapes the elevation in intracellular Ca2+ concentration ([Ca2+]i) may lead to severe pathological disorders, including cancer, chronic heartfailure, epileptic and neurodegenerative disorders, immunodeficiency, and developmental defects.An increase in [Ca2+]i is shaped by the concerted interaction among the components of an extremelyversatile network of channels, transporters, pumps, and buffers that can be uniquely assembled byeach cell type to generate intracellular Ca2+ signals with spatio-temporal properties precisely tailoredto regulate specific functions. |
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| Item Description: | http://oer.library.unej.ac.id//index.php?p=show_detail&id=496 612 |