PENGARUH PEMBERIAN EKSTRAK KAEMFERIA GALANGA L(KENCUR) TERHADAP EKSPRESI COX-2 DAN PENGHAMBATAN UKURAN TUMOR PADA ADENOKARSINOMA MAMMA MENCIT C3H
Background: Treatment of breast cancer using traditional plant are still used by patients. We want to know effect of kencur extract (Kaemferia Galanga L) or etil p- metiksisinamat which has effect. as anti inflammation. Inflammation is one of the causes of cancer because it can increase the growth o...
Saved in:
| Main Author: | |
|---|---|
| Format: | Academic Paper |
| Published: |
2015.
|
| Subjects: | |
| Online Access: | http://eprints.undip.ac.id/46849/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| LEADER | 02952 am a22002653u 4500 | ||
|---|---|---|---|
| 001 | repository_undip_46849_ | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Subiyakto, Subiyakto |e author |
| 245 | 0 | 0 | |a PENGARUH PEMBERIAN EKSTRAK KAEMFERIA GALANGA L(KENCUR) TERHADAP EKSPRESI COX-2 DAN PENGHAMBATAN UKURAN TUMOR PADA ADENOKARSINOMA MAMMA MENCIT C3H |
| 260 | |c 2015. | ||
| 500 | |a http://eprints.undip.ac.id/46849/1/COVER_-_ABSTRAK.pdf | ||
| 500 | |a http://eprints.undip.ac.id/46849/2/BAB_1.pdf | ||
| 500 | |a http://eprints.undip.ac.id/46849/3/BAB_2.pdf | ||
| 500 | |a http://eprints.undip.ac.id/46849/4/BAB_3.pdf | ||
| 500 | |a http://eprints.undip.ac.id/46849/5/BAB_4.pdf | ||
| 500 | |a http://eprints.undip.ac.id/46849/6/BAB_5.pdf | ||
| 500 | |a http://eprints.undip.ac.id/46849/7/BAB_6.pdf | ||
| 500 | |a http://eprints.undip.ac.id/46849/8/BAB_7.pdf | ||
| 500 | |a http://eprints.undip.ac.id/46849/9/DAFTAR_PUSTAKA.pdf | ||
| 520 | |a Background: Treatment of breast cancer using traditional plant are still used by patients. We want to know effect of kencur extract (Kaemferia Galanga L) or etil p- metiksisinamat which has effect. as anti inflammation. Inflammation is one of the causes of cancer because it can increase the growth of abnormal cells that improve cancer cells Methods: pre and post test design on 24 C3H mices was divided into 4 groups: group 1(K, control), group 2(PI, kencur extract 100mg/kgBW/day), group 2(PII, 150mg/kgBW/day), group 3(PIII, 200mg/kgBW/day). After tumor inoculation, initial tumor diameter was measured, given treatment for 3 weeks, post treatment tumor diameter measurement, and then measuring Cox-2 expression. Anova test was conducted and then Post Hoc correlation test. Results: Found out decreased on Cox-2 expression variable between groups with overall p<0.001 (significant). Tumor diameter difference with variable difference test showed significant result for group K(p= <0,001), PI(p= <0,001), PII(p=0.021)and group, but insignificant for group PIII(p=0.021).We found mean decrease of Cox-2 expression (K=37,8;PI=30,0;PII=25,4;PIII=22,5) and mean decrease of tumor diameter difference (K=4,78;PI=3,16;PII=2,17;PIII=1,29),and with Spearman correlation test found significant possitive correlation(p= < 0,001) with correlation coefficient (r=0.436 very strong). Conclusion: Kencur extract decrease expression of Cox-2 adenocarcinoma C3H mice significantly, as well as inhibiting the growth of tumor mass is offset diameter of the tumor. Spearman correlation test showed a decrease in the expression of Cox-2 and decrease the difference in tumor diameter was significantly associated with the strength of the correlation is very strong. Keywords: Kencur (Kaemferia Galanga L), Cox 2 expression, diameter of the tumor, adenocarcinoma mammae | ||
| 690 | |a R Medicine (General) | ||
| 655 | 7 | |a Thesis |2 local | |
| 655 | 7 | |a NonPeerReviewed |2 local | |
| 787 | 0 | |n http://eprints.undip.ac.id/46849/ | |
| 856 | 4 | 1 | |u http://eprints.undip.ac.id/46849/ |